Highly efficient photo-driven generation and elimination of reactive oxygen species in biological environment by gold nanoclusters

被引:2
|
作者
Li, Zenan [1 ]
Zhang, Tianyang [1 ]
Shen, Jian [1 ]
Ma, Yurong [1 ]
Yu, Kai [1 ]
Li, Jiacheng [1 ]
Huang, Hui [1 ]
Liu, Yang [1 ]
Kang, Zhenhui [1 ,2 ]
机构
[1] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China
[2] Macau Univ Sci & Technol, Macao Inst Mat Sci & Engn MIMSE, MUST SUDA Joint Res Ctr Adv Funct Mat, Taipa 999078, Peoples R China
来源
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING | 2023年 / 11卷 / 06期
基金
中国国家自然科学基金;
关键词
Reactive oxygen species; Photocatalysis; Gold nanoclusters; Oxygen reduction reaction; NANOPARTICLES; MECHANISM;
D O I
10.1016/j.jece.2023.111546
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Reactive oxygen species (ROS) play an essential role in cell signalling, pathogen defence, and maintaining cellular homeostasis. The photocatalysts are highly desired in the photo-driven in-situ ROS generation and elimination in biological environment. Here, we present the highly efficient photo-driven generation and elimination of ROS in biological environment by glutathione (GSH)-protected gold nanoclusters (AuNCs). In extracellular environment, AuNCs can generate hydrogen peroxide (H2O2) through a two-electron oxygen reduction reaction (ORR) without any additional sacrifices. On the other hand, in intracellular environment, AuNCs are capable of eliminating the ROS in cells under visible light. For the photocatalyst of GSH protected AuNCs, the photogenerated electrons are in response to reduction reactions, and meanwhile photogenerated holes can oxidize the GSH ligands, protecting other biomolecules from oxidation reactions. This work opens a new gate for the concentration manipulation of ROS in the biological environment as well as the real-time regulation of ROS in organisms.
引用
收藏
页数:10
相关论文
共 50 条
  • [21] Assessing the stability and reactive oxygen species generation of thiolate-protected nanoclusters in physiological conditions
    Harrington, Kristen
    Aminfar, Parimah
    Stamplecoskie, Kevin G.
    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 2025, 462
  • [22] Reactive oxygen species generation and photo-cytotoxicity of eugenol in solutions of various pH
    Atsumi, T
    Iwakura, I
    Fujisawa, S
    Ueha, T
    BIOMATERIALS, 2001, 22 (12) : 1459 - 1466
  • [23] Effects of oligosaccharides and polysaccharides on the generation of reactive oxygen species in different biological systems
    Radman, Romeo
    Bland, Elliot James
    Sangworachat, Nuntaka
    Bucke, Christopher
    Keshavarz, Tajalli
    BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 2006, 44 (129-133) : 129 - 133
  • [24] Intensifying Upconverted Ultraviolet Emission towards Efficient Reactive Oxygen Species Generation
    Zhang, Haoran
    Liu, Yachong
    Jin, Rong
    Han, Sanyang
    Su, Qianqian
    CHEMISTRY-AN ASIAN JOURNAL, 2022, 17 (15)
  • [25] ENHANCED GENERATION OF REACTIVE OXYGEN SPECIES USING GOLD NANOPARTICLES CONJUGATED WITH PROTOPORPHYRIN IX
    Oo, Maung Kyaw Khaing
    Gomez, Maria
    Wang, Hongjun
    Du, Henry
    NEMB2010: PROCEEDINGS OF THE ASME FIRST GLOBAL CONGRESS ON NANOENGINEERING FOR MEDICINE AND BIOLOGY - 2010, 2010, : 93 - 94
  • [26] Gold Nanocluster-Decorated Nanocomposites with Enhanced Emission and Reactive Oxygen Species Generation
    Xia, Junhan
    Wang, Xiaoyu
    Zhu, Shuxian
    Liu, Lu
    Li, Lidong
    ACS APPLIED MATERIALS & INTERFACES, 2019, 11 (07) : 7369 - 7378
  • [27] Fe vacancies in FeOCl enhanced reactive oxygen species generation for photocatalytic elimination of emerging pollutants
    Nie, Zixuan
    Sui, Chengji
    Xie, Xiaobin
    Ni, Shou-Qing
    Kong, Lingshuai
    Wang, Yifeng
    Zhan, Jinhua
    APPLIED CATALYSIS B-ENVIRONMENT AND ENERGY, 2024, 347
  • [28] Photo-oxidation of particle phase iron species dominates the generation of reactive oxygen species in secondary aerosol
    Jiang, Sabrina Yanan
    Gali, Nirmal Kumar
    Ruan, Huada Daniel
    Ning, Zhi
    SCIENCE OF THE TOTAL ENVIRONMENT, 2020, 723
  • [29] Singlet Oxygen Generation Using Thiolated Gold Nanoclusters under Photo- and Ultrasonic Excitation: Size and Ligand Effect
    Yagi, Junichi
    Ikeda, Atsuya
    Wang, Liu-Chun
    Yeh, Chen-Sheng
    Kawasaki, Hideya
    JOURNAL OF PHYSICAL CHEMISTRY C, 2022, 126 (46): : 19693 - 19704
  • [30] Reactive oxygen species self-scavenging nanomicelles for highly efficient gene transfection
    Wang, Long-Hai
    You, Ye-Zi
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252