Severe Asthma Network Italy Definition of Clinical Remission in Severe Asthma: A Delphi Consensus

被引：47

作者：

Canonica, Giorgio Walter ^{[1
,2
]}

Blasi, Francesco ^{[3
,4
,5
]}

Carpagnano, Giovanna Elisiana ^{[6
,7
]}

Guida, Giuseppe ^{[8
,9
]}

Heffler, Enrico ^{[1
,2
]}

Paggiaro, Pierluigi ^{[10
]}

Allegrini, Chiara ^{[11
]}

Antonelli, Andrea ^{[12
]}

Aruanno, Arianna ^{[13
]}

Bacci, Elena ^{[14
]}

Bagnasco, Diego ^{[15
]}

Beghe, Bianca ^{[16
]}

Bonavia, Marco ^{[17
]}

Bonini, Matteo ^{[18
]}

Brussino, Luisa ^{[19
]}

Caiaffa, Maria Filomena ^{[20
]}

Calabrese, Cecilia ^{[21
]}

Camiciottoli, Gianna ^{[11
]}

Caminati, Marco ^{[22
]}

Caruso, Cristiano ^{[13
,23
]}

Cavallini, Mirta ^{[24
]}

Bianchi, Fulvia Chieco ^{[25
]}

Conte, Maria Elisabetta ^{[26
]}

Corsico, Angelo Guido ^{[27
]}

Cosmi, Lorenzo ^{[28
]}

Costantino, Mariateresa ^{[29
]}

Costanzo, Giulia ^{[30
]}

Crivellaro, Mariaangiola ^{[25
]}

D'Alo, Simona ^{[31
]}

D'Amato, Mariella ^{[32
]}

Detoraki, Aikaterini ^{[33
]}

Di Proietto, Maria Carmela ^{[33
]}

Facciolongo, Nicola Cosimo ^{[35
]}

Ferri, Sebastian ^{[1
]}

Fierro, Vincenzo ^{[36
]}

Foschino, Maria Pia ^{[37
]}

Latorre, Manuela ^{[38
]}

Lombardi, Carlo ^{[39
]}

Macchia, Luigi ^{[40
]}

Milanese, Manlio ^{[41
]}

Montagni, Marcello ^{[42
]}

Parazzini, Elena Maria ^{[43
]}

Parente, Roberta ^{[44
]}

Passalacqua, Giovanni ^{[45
]}

Patella, Vincenzo ^{[46
]}

Pelaia, Girolamo ^{[47
]}

Pini, Laura ^{[48
]}

Puggioni, Francesca ^{[1
]}

Ricciardi, Luisa ^{[49
]}

Ridolo, Erminia ^{[50
]}

机构：

[1] IRCCS Humanitas Res Hosp, Personalized Med Asthma & Allergy, Via Manzoni 56, I-20089 Milan, Italy

[2] Humanitas Univ, Dept Biomed Sci, Milan, Italy

[3] Fdn IRCCS Ca Granda Osped Maggiore, Resp Unit, Policlin Milano, Milan, Italy

[4] Policlin Milano, Fdn IRCCS Ca Granda Osped Maggiore, Cyst Fibrosis Ctr, Milan, Italy

[5] Univ Milan, Dept Pathophysiol & Transplantat, Milan, Italy

[6] Univ Bari Aldo Moro, Dept Translat Biomed & Neurosci DiBraiN, Bari, Italy

[7] Policlin Hosp Bari, Sect Resp Dis, Bari, Italy

[8] Univ Turin, Dept Clin & Biol Sci, Turin, Italy

[9] San Luigi Gonzaga Univ Hosp, Severe Asthma & Rare Lung Dis Unit, Orbassano, Italy

[10] Univ Pisa, Dept Surg Med Mol Biol & Crit Care, Pisa, Italy

[11] Azienda Osped Univ Careggi, Ambulatorio Asma Grave Pneumol & Fisiopatol Toraco, Azienda Ospedaliera Universitaria Careggi, Florence, Italy

[12] Osped S Croce & Carle, Responsabile SS Allergol & Fisiopatol Resp, Cuneo, Italy

[13] Univ Cattolica Roma, Ist Clin Med, Allergol, Policlin Gemelli, Rome, Italy

[14] Fisiopatol Resp & Riabilitaz, Azienda Osped Univ Pisana, Pisa, Italy

[15] UO Clin Malattie Respiratorie & Allergol, UO Clin Malattie Resp & Allergol, San Martino Buon Albergo, Italy

[16] Univ Modena & Reggio Emilia, Dept Med & Surg Sci Maternal Infant & Adult, Sect Resp Dis, Emilia Romagna, Italy

[17] Osped Colletta, Dipartimento Special Med, SS Pneumol Riabilitat, SC Pneumol, Genoa, Italy

[18] Fdn Policlin Univ A Gemelli, UOC Pneumol, IRCCS, Rome, Italy

[19] SSDDU Immunol Clin Allergol, SSDDU Immunol Clin & Allergol, Turin, Italy

[20] Azienda Osped Univ, Dipartimenti funzioni Med & Sanitarie, Azienda Ospedaliero Universitaria, Osped Riuniti, Foggia, Italy

[21] Azienda Osped Specialist Colli, Dipartimento Pneumol & Oncol, UO Clin Pneumol SUN, Naples, Italy

[22] Azienda Osped Univ Integrata Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

[23] Fdn Policlin A Gemelli IRCCS, UOSD DH Internal Med & Digest Dis, Rome, Italy

[24] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Broncopneumol, Milan, Italy

[25] UOC Fisiopaol Respiratoria, UOC Fisiopaol Resp, Padua, Italy

[26] Struttura Complessa Pneumol, Azienda Assistenza Sanit 5 Friuli Occidentale, Pordenone, Italy

[27] Fdn IRCCS Policlin San Matteo, UOC Pneumol, Pavia, Italy

[28] AOUC Azienda Osped Univ Careggi, AOUC Azienda Ospedaliero Universitaria Careggi, Florence, Italy

[29] ASST Azienda Socio Sanitaria Terr Mantova, Osped Carlo Poma, Dipartimento Med, Ctr Day Hosp,Allergol & Immunol Clin, Mantua, Italy

[30] Policlin Univ Cagliari, Allergol & Immunol Clin, Cagliari, Italy

[31] UO Allergol, Azienda Sanit Unica Reg Marche, Civitanova Marche, Marche, Italy

[32] Azienda Osped Colli, UOC Pneumofisiol, Univ Federico II, Naples, Italy

[33] UODS Allergol Immunodeficienze, Azienda Osped Univ Federico II, Naples, Italy

[34] ASST Grande Osped Metropolitano Niguarda, SC Pneumol, Milan, Italy

[35] UOC Pneumol, Arcispedale S Maria Nuova Azienda USL Reggio Emili, Emilia Romagna, Italy

[36] Osped Pediat Bambino Gesu, UOC Allergol, Rome, Italy

[37] Azienda Osped Univ, Azienda Ospedaliera Universitaria, Foggia, Italy

[38] Osped Nuovo Apuano Massa, UO Pneumol, Massa, Italy

[39] Fdn Poliambulanza Ist Osped, Unita Allergol Immunol & Malattie Resp, Brescia, Italy

[40] Un Dipartimentale Allergol & Immunol Clin, Unita Dipartimentale Allergol & Immunol Clin, Bari, Italy

[41] Osped S Corona, Dipartimento Special Med, SC Pneumol, Pietra Ligure, Savona, Italy

[42] Osped G Saliceto Piacenza, Piacenza, Italy

[43] St i Paolo & Carlo Hosp, Otolaryngol Unit, Milan, Italy

[44] AOU San Giovanni di Dio & Ruggi di Aragona, Salerno, Italy

[45] Aou San Martino Ist Ge, IRCCS, Dip Med Interna, Genoa, Italy

[46] UO Allergol Immunol Clin, Azienda Sanit, Florence, Italy

[47] AOU Mater Domini, Catanzaro, Italy

[48] ASST Spedali Civili Brescia, UOC, Med Gen 2, Brescia, Italy

[49] Univ Messina, Dept Neurosurg, AOU Policlin G Martino, Messina, Italy

[50] Azienda Osped Univ Parma, Ambulatorio Allergol & Immunol Clin, AziendaOspedaliero, Parma, Italy

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2023年 / 11卷 / 12期

关键词：

Asthma; Asthma remission; Allergy; Inflammation; Delphi analysis; MANAGEMENT;

D O I：

10.1016/j.jaip.2023.07.041

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

analysis. Thirty-two statements were included in the R1 questionnaire and then submitted to a panel of 80 experts, which used a 5 -point Likert scale to measure agreement regarding each statement. Then, an interim analysis of R1 data was performed, and items were discussed and considered to produce a consistent questionnaire for round 2 (R2) of the analysis. Then, the board set the R2 questionnaire, which included only important topics. Panelists were asked to vote on the statements in the R2 questionnaire afterward. During R2, the criteria of complete clinical remission (the absence of the need for oral corticosteroids, symptoms, exacerbations or attacks, and pulmonary function stability) and those of partial clinical remission (the absence of the need for oral corticosteroids, and two of three criteria: the absence of symptoms, exacerbations or attacks, and pulmonary stability) were confirmed. This Severe Asthma Network Italy Delphi analysis defined a valuable and independent tool that is easy to use, to test the efficacy of different treatments in patients with severe asthma enrolled into the SANI registry. (c) 2023 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY -NC -ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/). (J Allergy Clin Immunol Pract 2023;11:3629-37)

引用

页码：3629 / 3637

页数：9

共 50 条

[41] Clinical Response and Remission in Patients With Severe Asthma Treated With Biologic Therapies
Hansen, Susanne
Sondergaard, Marianne Baastrup
von Bulow, Anna
Bjerrum, Anne-Sofie
Schmid, Johannes
Rasmussen, Linda M.
Johnsen, Claus R.
Ingebrigtsen, Truls
Hakansson, Kjell Erik Julius
Johansson, Sofie Lock
Bisgaard, Maria
Assing, Karin Dahl
Hilberg, Ole
Ulrik, Charlotte
Porsbjerg, Celeste
CHEST, 2024, 165 (02) : 253 - 266
[42] Relationship between FeNO suppression and Clinical Remission with Tezepelumab in Severe Asthma
Gates, Jessica
Haris, Faizan
Green, Linda
Lam, Jodie
Fernandes, Mariana
Thomson, Louise
Roxas, Cris
D'Ancona, Grainne
Dhariwal, Jaideep
Nanzer, Alexandra M.
Jackson, David J.
EUROPEAN RESPIRATORY JOURNAL, 2024, 64
[43] Chronic rhinosinusitis with nasal polyps impacts in severe asthma patients: Evidences from the Severe Asthma Network Italy (SANI) registry
Heffler, E.
Malvezzi, L.
Blasi, F.
Mantero, M.
Paggiaro, P.
Senna, G.
Caminati, M.
Canonica, G. W.
ALLERGY, 2020, 75 : 167 - 168
[44] Classification of asthma severity: Severe/not severe asthma or mild/moderate/severe asthma?
Yilmaz, Insu
Cetin, Guelden Pacaci
Arslan, Bahar
TUBERKULOZ VE TORAKS-TUBERCULOSIS AND THORAX, 2022, 70 (03): : 300 - 301
[45] Biologics as well as inhaled anti-asthmatic therapy achieve clinical remission: Evidence from the Severe Asthma Network in Italy (SANI)
Canonica, Giorgio Walter
Blasi, Francesco
Paggiaro, Pierluigi
Heffler, Enrico
Braido, Fulvio
Brussino, Luisa
Scioscia, Giulia
Cardini, Cristina
Oriecuia, Chiara
Sala, Isabella
Bagnardi, Vincenzo
WORLD ALLERGY ORGANIZATION JOURNAL, 2025, 18 (01):
[46] Clinical review: Severe asthma
Papiris S.
Kotanidou A.
Malagari K.
Roussos C.
Critical Care, 6 (1): : 30 - 44
[47] Clinical phenotypes of severe asthma
Sergeeva, G.
Emelyanov, A.
Leshenkova, E.
Znakhurenko, A.
Kozireva, L.
ALLERGY, 2015, 70 : 348 - 348
[48] Clinical review: Severe asthma
Papiris, S
Kotanidou, A
Malagari, K
Roussos, C
CRITICAL CARE, 2002, 6 (01): : 30 - 44
[49] Clinical characteristics of severe asthma
Spahn, JD
Covar, R
Brown, EE
Leung, DYM
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2000, 105 (01) : S284 - S285
[50] Severe asthma in the general population: definition and prevalence
Siroux, V
Pin, I
Pison, C
Kauffmann, F
REVUE DES MALADIES RESPIRATOIRES, 2004, 21 (05) : 961 - 969

← 1 2 3 4 5 →