Antithyroid Drug-Induced Agranulocytosis: A Case Report

被引：1
|
作者：
MacKay, Micaela [1 ]
Clewis, Madison C. [1 ]
Sweet, Patrick [1 ]
机构：
[1] Univ Texas Med Branch, Internal Med, Galveston, TX 77555 USA
来源：
CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 11期
关键词：
graves' disease; drug -induced agranulocytosis; antithyroid drugs; agranulocytosis; drug; -reaction; methimazole; HYPERTHYROIDISM;
D O I：
10.7759/cureus.48264
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Agranulocytosis is a rare but life-threatening complication of methimazole and propylthiouracil, antithyroid drugs (ATDs) prescribed for the treatment of hyperthyroidism. We report the case of a 41-year-old female who presented to our institution with complaints of fevers, chills, sore throat, myalgias, and generalized weakness one month after treatment initiation with methimazole. A complete blood count at admission revealed agranulocytosis with an absolute neutrophil count of 0/mu l. After discontinuation of the medication, she was treated with granulocyte-colony stimulating factor and intravenous broad-spectrum antibiotics, which improved her condition on day seven of hospitalization.
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