Large-cell Neuroendocrine Carcinoma of the Lung with Carcinoid Syndrome

被引：1

作者：

Yamamoto, Makoto ^{[1
]}

Ito, Renma ^{[1
]}

Tsujibata, Akihiko ^{[2
]}

Morita, Hiroko ^{[1
]}

Yoneda, Taro ^{[1
]}

Matano, Yutaka ^{[1
]}

Higashikata, Toshinori ^{[1
]}

机构：

[1] Komatsu Municipal Hosp, Dept Internal Med, Komatsu, Japan

[2] Komatsu Municipal Hosp, Dept Pathol, Komatsu, Japan

来源：

INTERNAL MEDICINE | 2023年 / 62卷 / 10期

关键词：

carcinoid syndrome; large cell neuroendocrine carcinoma of the lung; refractory diarrhea; EPIDEMIOLOGY; NEOPLASMS; TUMORS;

D O I：

10.2169/internalmedicine.0099-22

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 76-year-old woman was admitted to our hospital for refractory diarrhea with a poor antidiarrheal effect. Chest and abdominal computed tomography revealed a 24x22-mm mass in the left upper lobe of lung and multiple masses in the liver. Urine 5-Hydroxy indol acetic acid was markedly elevated. A liver biopsy revealed large-cell neuroendocrine carcinoma with serotonin production, suggestive of a lung origin, and a lung biopsy revealed combined large-cell neuroendocrine carcinoma and squamous cell carcinoma. Therefore, we made a definitive diagnosis of carcinoid syndrome caused by large-cell neuroendocrine carcinoma of the lung. Although chemotherapy was performed after diagnosis, the patient died 50 days postadmission.

引用

页码：1557 / 1563

页数：7

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