Sex and Gender in Ageing and Longevity: Highlights From an International Course

被引：1

作者：

Candore, Giuseppina ^{[1
,2
]}

Accardi, Giulia ^{[1
]}

Aiello, Anna ^{[1
]}

Baggio, Giovannella ^{[3
]}

Bellini, Tiziana ^{[4
,5
]}

Calabrese, Vittorio ^{[6
]}

Carreca, Anna P. ^{[7
]}

Carreca, Ignazio ^{[8
]}

Masucci, Anna ^{[2
,9
]}

Cattaneo, Monica ^{[10
]}

Dato, Serena ^{[11
,19
]}

Bona, Danilo D. ^{[12
]}

Fabris, Luca ^{[3
,13
,14
]}

Gambino, Caterina ^{[2
,9
]}

Lorenzo, Gabriele D. ^{[15
]}

Francescschi, Claudio ^{[16
,17
]}

Ligotti, Mattia E. ^{[18
]}

Manfrinato, Maria C. ^{[4
,5
]}

Puca, Annibale A. ^{[10
]}

Tamburello, Martina ^{[2
,9
]}

Vassallo, Roberta ^{[2
,9
]}

Caruso, Calogero ^{[1
]}

机构：

[1] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost, Lab Immunopathol & Immunosenescence, Palermo, Italy

[2] Univ Hosp P Giaccone, Dept Lab Med, Palermo, Italy

[3] Padua Univ Hosp, Italian Ctr Studies Gender Hlth & Med, Padua, Italy

[4] Univ Ferrara, Univ Ctr Studies Gender Med, Ferrara, Italy

[5] Univ Ferrara, Dept Neurosci & Rehabil, Ferrara, Italy

[6] Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy

[7] Ri MED Fdn, Palermo, Italy

[8] Univ Palermo, Dept Surg Oncol & Oral Sci, Sect Med Oncol, Palermo, Italy

[9] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost, Palermo, Italy

[10] IRCCS MultiMed, Cardiovasc Dept, Milan, Italy

[11] Univ Calabria, Dept Biol Ecol & Earth Sci, Arcavacata Di Rende, Italy

[12] Univ Foggia, Dept Med & Surg Sci, Foggia, Italy

[13] Univ Padua, Dept Med, Padua, Italy

[14] Yale Univ, Dept Internal Med, Digest Dis Sect, New Haven, CT USA

[15] Univ Palermo, Dept Hlth Promot Sci Maternal & Infant Care, Internal Med & Med Specialties, Palermo, Italy

[16] Lobachevsky State Univ, Inst Informat Technol Math & Mech, Nizhnii Novgorod, Russia

[17] Lobachevsky State Univ, Inst Biogerontol, Nizhnii Novgorod, Russia

[18] ISMETT IRCCS Mediterranean Inst Transplants & High, Dept Res, Palermo, Italy

[19] Univ Salerno, Dept Med Surg & Dent, Salerno, Italy

来源：

TRANSLATIONAL MEDICINE AT UNISA | 2024年 / 26卷 / 01期

关键词：

Ageing; Age-related diseases; Epigenetics; Gender; Genetics; Immune responses longevity; Sex; LUNG-CANCER; AGE; DISEASE; METHYLATION; EXPRESSION; AUTOIMMUNE; MEDICINE; FRAILTY; STRESS;

D O I：

10.37825/2239-9747.1049

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Gender medicine is a multidisciplinary science and represents an important perspective for pathophysiological and clinical studies in the third millennium. Here, it is provided an overview of the topics discussed in a recent course on the Role of Sex and Gender in Ageing and Longevity. The paper highlights three themes discussed in the course, i.e., the interaction of gender/sex with, i) the pathophysiology of age -related diseases; ii), the role of genetics and epigenetics in ageing and longevity and, iii) the immune responses of older people to pathogens, vaccines, autoantigens, and allergens. Although largely unexplored, it is clear that sex and gender are modulators of disease biology and treatment outcomes. It is becoming evident that men and women should no longer be considered as subgroups, but as biologically distinct groups of patients deserving consideration for specific therapeutic approaches.

引用

页数：17

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