A Pump-free Optofluidic Biosensing Platform based on Whispering Gallery Mode Microspheres

被引：0
|
作者：
Guan, Bin [1 ,2 ]
Kok, Tuck-Weng [3 ,4 ]
Riesen, Nicolas [1 ,2 ]
Lancaster, David G. [1 ,2 ]
Suu, Koukou [5 ]
Priest, Craig [1 ,2 ]
机构：
[1] Univ South Australia, Future Ind Inst, STEM, Mawson Lakes, SA 5095, Australia
[2] Univ South Australia, ARC Res Hub Integrated Devices End User Anal Low, Mawson Lakes, SA 5095, Australia
[3] Univ Adelaide, Adelaide Med Sch, Adelaide, SA 5005, Australia
[4] Univ Adelaide, Sch Biol Sci, Adelaide, SA 5005, Australia
[5] ULVAC Inc, Chigasaki, Kanagawa 2538543, Japan
来源：
2023 IEEE SENSORS | 2023年
基金：
澳大利亚研究理事会;
关键词：
optofluidics; biosensing; micropillar array; whispering gallery mode; microsphere; influenza virus; VIRUSES;
D O I：
10.1109/SENSORS56945.2023.10325052
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Optofluidic biosensors offer significant advantages for lab-on-a-chip chemical and biological analysis by combining microfluidics for small-volume liquid manipulation with the high sensitivity and adaptability of optical sensing techniques. In this study, we present an optofluidic biosensing platform utilising a micropillar array coupled with active whispering gallery mode (WGM) microsphere resonators for the rapid detection of influenza viruses. The WGM microspheres are coated with polyclonal antibodies capable of targeting both intact virus and fragments of viral proteins. The micropillar array facilitates continuous sampling and measurement through evaporation-driven fluid transport.
引用
收藏
页数：4
相关论文
共 50 条
  • [21] Optofluidic Whispering Gallery Mode Microcapillary Lasers for Refractive Index Sensing
    Francois, Alexandre
    Riesen, Nicolas
    Gardner, Kirsty
    Monro, Tanya M.
    Meldrum, Al
    SPIE BIOPHOTONICS AUSTRALASIA, 2016, 10013
  • [22] Optimization of whispering gallery mode sensor design for applications in biosensing
    Reynolds, T.
    Francois, A.
    Henderson, M. R.
    Nicholls, S. J.
    Monro, T. M.
    DESIGN AND QUALITY FOR BIOMEDICAL TECHNOLOGIES VIII, 2015, 9315
  • [23] Whispering-gallery-mode biosensing: label-free detection down to single molecules
    Frank Vollmer
    Stephen Arnold
    Nature Methods, 2008, 5 : 591 - 596
  • [24] Whispering Gallery Mode Resonators for Rapid Label-Free Biosensing in Small Volume Droplets
    Wildgen, Sarah M.
    Dunn, Robert C.
    BIOSENSORS-BASEL, 2015, 5 (01): : 118 - 130
  • [25] Whispering-gallery-mode biosensing: label-free detection down to single molecules
    Vollmer, Frank
    Arnold, Stephen
    NATURE METHODS, 2008, 5 (07) : 591 - 596
  • [26] Pseudo Whispering Gallery Mode Optofluidic Lasing Based on Air-Clad Optical Fiber
    Gong, Chaoyang
    Gong, Yuan
    Yang, Xi
    Peng, Gang-Ding
    Rao, Yun-Jiang
    JOURNAL OF LIGHTWAVE TECHNOLOGY, 2019, 37 (11) : 2623 - 2627
  • [27] Hollow-Core Optical Fiber Optofluidic DNA Sensor Based on Whispering Gallery Mode
    Zhang Hongxin
    Li Xuegang
    Zhou Xue
    Zhang Yanan
    Zhao Yong
    ACTA OPTICA SINICA, 2024, 44 (09)
  • [28] A demonstration of multiplex biosensing using whispering gallery mode microspheres positioned onto a microstructured optical fiber tip
    Reynolds, T.
    Francois, A.
    Nicholls, S. J.
    Monro, T. M.
    OPTICAL DIAGNOSTICS AND SENSING XIV: TOWARD POINT-OF-CARE DIAGNOSTICS, 2014, 8951
  • [29] Bioimmunoassay based on hydrophobin HGFI self-assembled whispering gallery mode optofluidic microresonator
    Wu, Jixuan
    Wang, Bo
    Song, Binbin
    Qiao, Mingqiang
    Liu, Bo
    Zhang, Hao
    Lin, Wei
    Duan, Shaoxiang
    SENSORS AND ACTUATORS A-PHYSICAL, 2021, 319
  • [30] Flow rate sensor based on high-order whispering gallery mode in optofluidic microcavity
    Zhang, Xiang
    Feng, Xuan
    Zhu, Chao
    He, Maohui
    Zhao, Xuehua
    Xu, Jin
    Cao, Liu
    OPTICAL ENGINEERING, 2024, 63 (02)
12345