Accuracy of the VRF and VRF-G Intraocular Lens Power Calculation Formulas Using Swept-Source Optical Coherence Tomography Biometry

Purpose: To collate the accuracy of two recently introduced intraocular lens (IOL) formulas (VRF and VRF-G) in cataract patients using a swept-source optical coherence tomography (SS-OCT) biometry (IOL Master 700, Carl Zeiss Meditec AG, Jena, Germany). Patients and Methods: Data records of 295 eyes from 295 patients were included in this scrutiny. The IOLMaster 700 SS-OCT biometer was used for biometric measurements. The VRF and VRF-G formulas were compared with seven 3rd and 4th generation thin and thick-lens formulas: Haigis, Hoffer Q, Holladay 1, Holladay 2, SRK/T, T2, and Barrett Universal II. With optimized lens constants, the mean prediction error (PE) and its standard deviation (SD), the median absolute error (MedAE), the mean absolute error (MAE), and the percentage of eyes with PEs within +/- 0.25 D, +/- 0.50 D, +/- 0.75 D, +/- 1.00 D, and <+/- 2.00 D were analyzed.Results: Statistically significant differences were found between formulas in the whole group (Friedman test, P = 0.000). The VRF-G and Haigis formulas showed the lowest SD values (0.464 D and 0.466 D respectively). The VRF and Barrett Universal II formulas were less predictable (SD 0.471 D and SD 0.474 D respectively). The biggest proportion of eyes within +/- 0.50 D was found with VRF-G (76.27%), Haigis (75.59%), VRF (74.92%), and Barrett Universal II (74.92%) formulas.Conclusion: Based on data achieved from the SS-OCT biometry, the VRF-G and Haigis methods were the more precise predictors of postoperative refraction with the biggest proportion of eyes within +/- 0.50 D.