Vanadium compounds as antiparasitic agents: An approach to their mechanisms of action

被引：6

作者：

Brenda, Casarrubias-Tabarez ^{[1
,2
,3
]}

Norma, Rivera-Fernandez ^{[1
,4
]}

Marcela, Rojas-Lemus ^{[1
,2
]}

Nelly, Lopez-Valdez ^{[1
,2
]}

Teresa, I. Fortoul ^{[1
,2
]}

机构：

[1] Ave Ciudad Unive 3000, Mexico City 04510, Mexico

[2] Univ Nacl Autonoma Mexico, Sch Med, Dept Cellular & Tissue Biol, Mexico City 04510, Mexico

[3] Univ Nacl Autonoma Mexico, Posgrad Ciencias Biol, Mexico City 04510, Mexico

[4] Univ Nacl Autonoma Mexico, Parasitol Sch Med, Dept Microbiol, Mexico City 04510, Mexico

来源：

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY | 2023年 / 78卷

关键词：

Vanadium; Action mechanisms; Malaria; Leishmaniasis; trypanosomiasis; Metallic compounds; HETEROLEPTIC OXIDOVANADIUM(IV) COMPOUNDS; TRYPANOSOMA-CRUZI; LEISHMANICIDAL ACTIVITY; OXIDATIVE STRESS; SALICYLALDEHYDE SEMICARBAZONES; BIOLOGICAL-ACTIVITIES; POLYPYRIDYL LIGANDS; COMPLEXES; VANADATE; DERIVATIVES;

D O I：

10.1016/j.jtemb.2023.127201

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Parasitic infections are a public health problem since they have high morbidity and mortality worldwide. In parasitosis such as malaria, leishmaniasis and trypanosomiasis it is necessary to develop new compounds for their treatment since an increase in drug resistance and toxic effects have been observed. Therefore, the use of different compounds that couple vanadium in their structure and that have a broad spectrum against different parasites have been proposed experimentally.Objective: Report the mechanisms of action exerted by vanadium in different parasites.Conclusion: In this review, some of the targets that vanadium compounds have were identified and it was observed that they have a broad spectrum against different parasites, which represents an advance to continue investigating therapeutic options.

引用

页数：8

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