The Synergic Effect of AT(N) Profiles and Depression on the Risk of Conversion to Dementia in Patients with Mild Cognitive Impairment

被引：8

作者：

Marquie, Marta ^{[1
,2
]}

Garcia-Gutierrez, Fernando ^{[1
]}

Orellana, Adelina ^{[1
,2
]}

Montrreal, Laura ^{[1
]}

de Rojas, Itziar ^{[1
,2
]}

Garcia-Gonzalez, Pablo ^{[1
]}

Puerta, Raquel ^{[1
]}

Olive, Claudia ^{[1
]}

Cano, Amanda ^{[1
,2
]}

Hernandez, Isabel ^{[1
]}

Rosende-Roca, Maitee ^{[1
]}

Vargas, Liliana ^{[1
]}

Tartari, Juan Pablo ^{[1
]}

Esteban-De Antonio, Ester ^{[1
]}

Bojaryn, Urszula ^{[1
]}

Ricciardi, Mario ^{[1
]}

Ariton, Diana M. ^{[1
]}

Pytel, Vanesa ^{[1
]}

Alegret, Montserrat ^{[1
,2
]}

Ortega, Gemma ^{[1
,2
]}

Espinosa, Ana ^{[1
,2
]}

Perez-Cordon, Alba ^{[1
]}

Sanabria, Angela ^{[1
,2
]}

Munoz, Nathalia ^{[1
]}

Lleonart, Nuria ^{[1
]}

Aguilera, Nuria ^{[1
]}

Garcia-Sanchez, Ainhoa ^{[1
]}

Alarcon-Martin, Emilio ^{[1
]}

Tarraga, Lluis ^{[1
,2
]}

Ruiz, Agustin ^{[1
,2
]}

Boada, Merce ^{[1
,2
]}

Valero, Sergi ^{[1
,2
]}

机构：

[1] Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona 08028, Spain

[2] Inst Salud Carlos III, Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid 28029, Spain

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 02期

关键词：

mild cognitive impairment (MCI); dementia; CSF; NPSs; interaction; synergic; MINI-MENTAL STATE; ALZHEIMERS-DISEASE; NEUROPSYCHIATRIC SYMPTOMS; DIAGNOSTIC-CRITERIA; OLDER; INDIVIDUALS; CONSENSUS; ASSOCIATION; BIOMARKERS; BATTERY;

D O I：

10.3390/ijms24021371

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Few studies have addressed the impact of the association between Alzheimer's disease (AD) biomarkers and NPSs in the conversion to dementia in patients with mild cognitive impairment (MCI), and no studies have been conducted on the interaction effect of these two risk factors. AT(N) profiles were created using AD-core biomarkers quantified in cerebrospinal fluid (CSF) (normal, brain amyloidosis, suspected non-Alzheimer pathology (SNAP) and prodromal AD). NPSs were assessed using the Neuropsychiatric Inventory Questionnaire (NPI-Q). A total of 500 individuals with MCI were followed-up yearly in a memory unit. Cox regression analysis was used to determine risk of conversion, considering additive and multiplicative interactions between AT(N) profile and NPSs on the conversion to dementia. A total of 224 participants (44.8%) converted to dementia during the 2-year follow-up study. Pathologic AT(N) groups (brain amyloidosis, prodromal AD and SNAP) and the presence of depression and apathy were associated with a higher risk of conversion to dementia. The additive combination of the AT(N) profile with depression exacerbates the risk of conversion to dementia. A synergic effect of prodromal AD profile with depressive symptoms is evidenced, identifying the most exposed individuals to conversion among MCI patients.

引用

页数：15

共 50 条

[41] Outdoor artificial light at night and risk of conversion from mild cognitive impairment to dementia
Filippini, T.
Costanzini, S.
Chiari, A.
Urbano, T.
Despini, F.
Tondelli, M.
Bedin, R.
Zamboni, G.
Teggi, S.
Vinceti, M.
EUROPEAN JOURNAL OF PUBLIC HEALTH, 2024, 34
[42] Taxifolin for Cognitive Preservation in Patients with Mild Cognitive Impairment or Mild Dementia
Hattori, Yorito
Saito, Satoshi
Nakaoku, Yuriko
Ogata, Soshiro
Hattori, Masashi
Nakatsuji, Mio
Nishimura, Kunihiro
Ihara, Masafumi
JOURNAL OF ALZHEIMERS DISEASE, 2023, 93 (02) : 743 - 754
[43] Neuropsychiatric symptoms and faster progression of cognitive impairments as predictors of risk of conversion of mild cognitive impairment to dementia
Bidzan, Mariola
Bidzan, Leszek
Bidzan-Bluma, Ilona
ARCHIVES OF MEDICAL SCIENCE, 2017, 13 (05) : 1168 - 1177
[44] Plasma fibrinogen is associated with cognitive decline and risk for dementia in patients with mild cognitive impairment
Xu, G.
Zhang, H.
Zhang, S.
Fan, X.
Liu, X.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2008, 62 (07) : 1070 - 1075
[45] Conversion from subtypes of mild cognitive impairment to Alzheimer dementia
Hussain, Hadi
NEUROLOGY, 2007, 69 (04) : 409 - 409
[46] Are depressive symptoms in mild cognitive impairment predictive of conversion to dementia?
De Roeck, Ellen
Ponjaert-Kristoffersen, Ingrid
Bosmans, Marc
De Deyn, Peter Paul
Engelborghs, Sebastiaan
Dierckx, Eva
INTERNATIONAL PSYCHOGERIATRICS, 2016, 28 (06) : 921 - 928
[47] Incidence of Mild Cognitive Impairment, Conversion to Probable Dementia, and Mortality
Zhang, Yun
Natale, Ginny
Clouston, Sean
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS, 2021, 36
[48] Conversion from subtypes of mild cognitive impairment to Alzheimer dementia
Fischer, P.
Jungwirth, S.
Zehetmayer, S.
Weissgram, S.
Hoenigschnabl, S.
Gelpi, E.
Krampla, W.
Tragl, K. H.
NEUROLOGY, 2007, 68 (04) : 288 - 291
[49] INCIDENCE OF MILD COGNITIVE IMPAIRMENT, CONVERSION TO PROBABLE DEMENTIA, AND MORTALITY
Zhang, Yun
Natale, Ginny
Clouston, Sean
INNOVATION IN AGING, 2021, 5 : 645 - 645
[50] Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type -: A prospective cohort study
Modrego, PJ
Ferrández, J
ARCHIVES OF NEUROLOGY, 2004, 61 (08) : 1290 - 1293

← 1 2 3 4 5 →