Outbreak of severe community-acquired bacterial infections among children in North Rhine-Westphalia (Germany), October to December 2022

被引：1

作者：

Goretzki, Sarah C. ^{[1
]}

van der Linden, Mark ^{[2
]}

Itzek, Andreas ^{[2
]}

Huehne, Tom ^{[1
]}

Adelmann, Roland O. ^{[3
]}

Eldin, Firas Ala ^{[4
]}

Albarouni, Mohamed ^{[5
]}

Becker, Jan-Claudius ^{[6
]}

Berghaeuser, Martin A. ^{[7
]}

Boesing, Thomas ^{[8
]}

Boeswald, Michael ^{[9
]}

Brasche, Milian ^{[10
]}

Nunez, Francisco ^{[11
]}

Camara, Rokya ^{[12
]}

Deibert, Clara ^{[13
]}

Dohle, Frank ^{[14
]}

Dolgner, Joerg ^{[15
]}

Dziobaka, Jan ^{[16
]}

Eifinger, Frank ^{[17
]}

Elting, Natalie ^{[18
]}

Endmann, Matthias ^{[19
]}

Engelmann, Guido ^{[20
]}

Frenzke, Holger ^{[21
]}

Gappa, Monika ^{[22
]}

Gharavi, Bahman ^{[23
]}

Goletz, Christine ^{[24
]}

Hahn, Eva ^{[25
]}

Heidenreich, Yvonne ^{[26
]}

Heimann, Konrad ^{[10
]}

Hensel, Kai O. ^{[27
]}

Hoffmann, Hans-Georg ^{[28
]}

Hoppenz, Marc ^{[29
]}

Horneff, Gerd ^{[30
]}

Klassen, Helene ^{[31
]}

Koerner-Rettberg, Cordula ^{[32
]}

Laengler, Alfred ^{[33
]}

Lenz, Pascal ^{[34
]}

Lohmeier, Klaus ^{[35
]}

Mueller, Andreas ^{[36
]}

Niemann, Frank ^{[5
]}

Paulussen, Michael ^{[37
]}

Pentek, Falk ^{[38
]}

Perez, Ruy ^{[39
]}

Pingel, Markus ^{[40
]}

Repges, Philip ^{[41
]}

Rothoeft, Tobias ^{[42
]}

Ruebo, Jochen ^{[43
]}

Schade, Herbert ^{[44
]}

Schmitz, Robert ^{[45
]}

Schonhoff, Peter ^{[46
]}

机构：

[1] Univ Hosp Essen, Univ Duisburg Essen, Dept Pediat 1, Neonatol Pediat Intens Care Pediat Neurol & Pediat, Essen, Germany

[2] Univ Hosp RWTH Aachen, Dept Med Microbiol, German Reference Lab Streptococci, Aachen, Germany

[3] Dept Gen Pediat, Klinikum Oberberg, Kreiskrankenhaus Gummersbach, Gummersbach, Germany

[4] Helios Hosp Schwelm, Dept Gen Pediat, Schwelm, Germany

[5] Marien Hosp Gelsenkirchen, Dept Gen Pediat, Gelsenkirchen, Germany

[6] Agaples Hosp Hagen, Dept Pediat, Hagen, Germany

[7] Florence Nightingale Hosp Kaiserswerth, Dept Pediat, Div Pediat Intens Care, Dusseldorf, Germany

[8] Univ Bielefeld, Protestant Hosp Bethel, Dept Pediat, Div Pediat Intens Care, Bielefeld, Germany

[9] Sankt Franziskus Hosp Munster, Dept Pediat, Munster, Germany

[10] Univ Hosp, RWTH Univ Aachen, Dept Pediat, Div Neonatol, Aachen, Germany

[11] Sana Hosp Duisburg, Dept Pediat, Div Pediat Intens Care, Duisburg, Germany

[12] GFO Hosp Bonn, Dept Pediat & Adolescent Med, Div Neonatol, Bonn, Germany

[13] DRK Hosp Kirchen, Dept Gen Pediat, Kirchen, Germany

[14] St Vinzenz Hosp Paderborn, Dept Pediat, Pediat Intens Care Med, Paderborn, Germany

[15] GFO Hosp Dinslaken, Dept Gen Pediat, Dinslaken, Germany

[16] Univ Hosp Essen, Univ Duisburg Essen, Dept Microbiol, Essen, Germany

[17] Univ Hosp, Univ Cologne, Dept Pediat, Div Pediat Intens Care, Cologne, Germany

[18] Evangel Hosp Oberhausen, Dept Gen Pediat, Oberhausen, Germany

[19] St Franziskus Hosp Ahlen, Dept Gen Pediat, Ahlen, Germany

[20] Lukas Hosp Neuss, Dept Gen Pediat, Neuss, Germany

[21] Mark Hosp Ludenscheid, Dept Gen Pediat, Ludenscheid, Germany

[22] Evangelical Hosp Dusseldorf, Dept Gen Pediat, Dusseldorf, Germany

[23] Marien Hosp Witten, Dept Gen Pediat, Witten, Germany

[24] Elisabeth Hosp Rheydt, Dept Gen Pediat, Stadt Kliniken Monchengladbach, Monchengladbach, Germany

[25] Sankt Agnes Hosp, Dept Pediat & Adolescent Med, Bocholt, Germany

[26] Hosp Soest gGmbH, Dept Gen Pediat, Soest, Germany

[27] Helios Univ Hosp Wuppertal, Witten Herdecke Univ, Dept Pediat, Div Pediat Intens Care, Wuppertal, Germany

[28] Mathias Stiftung, Dept Gen Pediat, Rheine, Germany

[29] Childrens Hosp, Dept Pediat, Div Pediat Intens Care, Amsterdamer Str, Cologne, Germany

[30] Asklepios Clin Sankt Augustin GmbH, Dept Pediat, St Augustin, Germany

[31] Hochsauerland Hosp, Dept Pediat & Adolescent Med, Arnsberg, Germany

[32] Marien Hosp gGmbH, Dept Gen Pediat, Wesel, Germany

[33] Univ Witten Herdecke, Dept Pediat, Gemeinschaftskrankenhaus Herdecke, Herdecke, Germany

[34] Hosp Leverkusen GmbH, Dept Gen Pediat, Leverkusen, Germany

[35] Heinrich Heine Univ, Dept Gen Pediat, Div Neonatol & Pediat Cardiol, Dusseldorf, Germany

[36] Univ Bonn, Dept Neonatol & Pediat Intens Care Med, Bonn, Germany

[37] Univ Witten Herdecke, Hosp Children & Adolescents, Dept Gen Pediat, Div Oncol & Haematol, Datteln, Germany

[38] Elisabeth Hosp Essen, Dept Pediat, Essen, Germany

[39] Helios Hosp Krefeld, Dept Pediat, Div Pediat Intens Care, Krefeld, Germany

[40] DRK Hosp Siegen gGmbH, Dept Gen Pediat, Siegen, Germany

[41] Dept Gen Pediat, Porz, Cologne, Germany

[42] Univ Childrens Hosp, Ruhr Univ Bochum, Div Neonatol & Pediat Intens Care, Bochum, Germany

[43] St Antonius Hosp Kleve, Dept Gen Pediat, Kleve, Germany

[44] Hosp Mechernich GmbH, Dept Gen Pediat, Mechernich, Germany

[45] Dept Pediat, Helios Clin Duisburg, Duisburg, Germany

[46] Clemenshosp Munster, Clemenshospital Munster, Munster, Germany

[47] Evangel Hosp Lippstadt, Dept Gen Pediat, Lippstadt, Germany

[48] Municipal Hosp Solingen, Dept Gen Pediat, Solingen, Germany

[49] Evangelical Hosp Hamm, Div Neonatol & Pediat Intens Care, Hamm, Germany

[50] Dept Gen Pediat, Herford, Germany

来源：

INFECTION | 2024年 / 52卷 / 3期

关键词：

Surveillance; Outbreak; Children; Bacterial infections; Community acquired infections; Germany; GROUP-A-STREPTOCOCCUS; DISEASE; SURVEILLANCE; PNEUMONIAE; IMPACT;

D O I：

10.1007/s15010-023-02165-x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

PurposeIn late 2022, a surge of severe S. pyogenes infections was reported in several European countries. This study assessed hospitalizations and disease severity of community-acquired bacterial infections with S. pyogenes, S. pneumoniae, N. meningitidis, and H. influenzae among children in North Rhine-Westphalia (NRW), Germany, during the last quarter of 2022 compared to long-term incidences.MethodsHospital cases due to bacterial infections between October and December 2022 were collected in a multicenter study (MC) from 59/62 (95%) children's hospitals in NRW and combined with surveillance data (2016-2023) from the national reference laboratories for streptococci, N. meningitidis, and H. influenzae. Overall and pathogen-specific incidence rates (IR) from January 2016 to March 2023 were estimated via capture-recapture analyses. Expected annual deaths from the studied pathogens were calculated from national death cause statistics.ResultsIn the MC study, 153 cases with high overall disease severity were reported with pneumonia being most common (59%, n = 91). IRs of bacterial infections declined at the beginning of the COVID-19 pandemic and massively surged to unprecedented levels in late 2022 and early 2023 (overall hospitalizations 3.5-fold), with S. pyogenes and S. pneumoniae as main drivers (18-fold and threefold). Observed deaths during the study period exceeded the expected number for the entire year in NRW by far (7 vs. 0.9).DiscussionThe unprecedented peak of bacterial infections and deaths in late 2022 and early 2023 was caused mainly by S. pyogenes and S. pneumoniae. Improved precautionary measures are needed to attenuate future outbreaks.

引用

页码：1099 / 1111

页数：13

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