Herein, a smartphone-based portable reader with integrated optics for standard microtiter plates (96 wells) has been designed and demonstrated for high-throughput quantitation of validated biomarkers in serum. The customized optical attachment was simply constructed with a convex lens and a light source, by which the transmitted light through a 96-well microtiter plate was converged for imaging with a smartphone, so that accurate and wide-range reading of the plate can be achieved. More importantly, relying on the digitized colorimetric analysis of the obtained images, concentrations of various biomarkers can be determined directly using the customized mobile app. A set of validated biomarkers for inflammation and infection, C-reactive protein (CRP), serum amyloid A (SAA), and procalcitonin (PCT) have been quantitated with this new system; both the response ranges and limits of detection meet the requirement of clinical tests. The consistency with the results obtained using a commercial microplate reader proves its reliability and precision, augments its potential as a point-of-care diagnostic device for on-site testing or resource-limited settings.
机构:
M Sechenov First Moscow State Med Univ Sechenov U, Moscow, Russia
Novosibirsk State Univ, Novosibirsk, Russia
Inst Cytol & Genet SB RAS, Novosibirsk, Russia
Peoples Friendship Univ Russia, Agrarian & Technol Inst, Moscow, RussiaM Sechenov First Moscow State Med Univ Sechenov U, Moscow, Russia
Orlov, Yuriy L.
Chen, Wen-Lian
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Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai, Peoples R ChinaM Sechenov First Moscow State Med Univ Sechenov U, Moscow, Russia
Chen, Wen-Lian
Sekacheva, Marina I.
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M Sechenov First Moscow State Med Univ Sechenov U, Moscow, RussiaM Sechenov First Moscow State Med Univ Sechenov U, Moscow, Russia
Sekacheva, Marina I.
Cai, Guoshuai
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Univ South Carolina, Arnold Sch Publ Hlth, Environm Hlth Sci, Columbia, SC USAM Sechenov First Moscow State Med Univ Sechenov U, Moscow, Russia
Cai, Guoshuai
Li, Hua
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Shanghai Jiao Tong Univ, Sch Biomed Engn, Bio ID Ctr, Shanghai, Peoples R ChinaM Sechenov First Moscow State Med Univ Sechenov U, Moscow, Russia
机构:
Michigan State Univ, Dept Chem Engn & Mat Sci, Biomass Convers Res Lab, E Lansing, MI 48824 USAMichigan State Univ, Dept Chem Engn & Mat Sci, Biomass Convers Res Lab, E Lansing, MI 48824 USA
Chundawat, Shishir P. S.
Balan, Venkatesh
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Michigan State Univ, Dept Chem Engn & Mat Sci, Biomass Convers Res Lab, E Lansing, MI 48824 USAMichigan State Univ, Dept Chem Engn & Mat Sci, Biomass Convers Res Lab, E Lansing, MI 48824 USA
Balan, Venkatesh
Dale, Bruce E.
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Michigan State Univ, Dept Chem Engn & Mat Sci, Biomass Convers Res Lab, E Lansing, MI 48824 USAMichigan State Univ, Dept Chem Engn & Mat Sci, Biomass Convers Res Lab, E Lansing, MI 48824 USA
机构:
Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Pang, Hei-Leung
Kwok, Hga-Yan
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Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Kwok, Hga-Yan
Chan, Pak-Ho
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Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Chan, Pak-Ho
Yeung, Chi-Hung
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Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Yeung, Chi-Hung
Lo, Waihung
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Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
Lo, Waihung
Wong, Kwok-Yin
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Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China