Fibroblast Growth Factor 21: A Fascinating Perspective on the Regulation of Muscle Metabolism

被引:4
|
作者
Li, Shuo [1 ]
Chen, Jun [1 ]
Wei, Panting [1 ]
Zou, Tiande [1 ]
You, Jinming [1 ]
机构
[1] Jiangxi Agr Univ, Jiangxi Prov Key Lab Anim Nutr, Nanchang 330045, Peoples R China
基金
中国国家自然科学基金;
关键词
FGF21; muscle metabolism; stress response; insulin signaling; myogenic development; ENDOPLASMIC-RETICULUM STRESS; SKELETAL-MUSCLE; INSULIN-RESISTANCE; FGF21; EXPRESSION; ACTIVATION; FGF-21; MTORC1; MASS; ASSOCIATION; HOMEOSTASIS;
D O I
10.3390/ijms242316951
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Fibroblast growth factor 21 (FGF21) plays a vital role in normal eukaryotic organism development and homeostatic metabolism under the influence of internal and external factors such as endogenous hormone changes and exogenous stimuli. Over the last few decades, comprehensive studies have revealed the key role of FGF21 in regulating many fundamental metabolic pathways, including the muscle stress response, insulin signaling transmission, and muscle development. By coordinating these metabolic pathways, FGF21 is thought to contribute to acclimating to a stressful environment and the subsequent recovery of cell and tissue homeostasis. With the emphasis on FGF21, we extensively reviewed the research findings on the production and regulation of FGF21 and its role in muscle metabolism. We also emphasize how the FGF21 metabolic networks mediate mitochondrial dysfunction, glycogen consumption, and myogenic development and investigate prospective directions for the functional exploitation of FGF21 and its downstream effectors, such as the mammalian target of rapamycin (mTOR).
引用
收藏
页数:19
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