The Role of Peroxisome Proliferator-Activated Receptors in Polycystic Ovary Syndrome

被引：6

作者：

Psilopatis, Iason ^{[1
,2
,3
,4
]}

Vrettou, Kleio ^{[4
]}

Nousiopoulou, Eleni ^{[4
]}

Palamaris, Kostas ^{[4
]}

Theocharis, Stamatios ^{[4
]}

机构：

[1] Charite Univ Med Berlin, Dept Gynecol, Augustenburger Pl 1, D-13353 Berlin, Germany

[2] Free Univ Berlin, Augustenburger Pl 1, D-13353 Berlin, Germany

[3] Humboldt Univ, Augustenburger Pl 1, D-13353 Berlin, Germany

[4] Natl & Kapodistrian Univ Athens, Med Sch, Dept Pathol 1, 75 Mikras Asias St,Bld 10, Athens 11527, Greece

来源：

JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 08期

关键词：

peroxisome proliferator-activated receptor; PPAR; polycystic ovary syndrome; PPAR-GAMMA LIGANDS; SUBCUTANEOUS ADIPOSE-TISSUE; PRO12ALA POLYMORPHISM; GENE-EXPRESSION; INSULIN-RESISTANCE; GRANULOSA-CELLS; SKELETAL-MUSCLE; CHINESE WOMEN; RAT MODEL; ASSOCIATION;

D O I：

10.3390/jcm12082912

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Polycystic ovary syndrome (PCOS) constitutes the most common endocrine disorder in women of reproductive age. Patients usually suffer from severe menstrual irregularities, skin conditions, and insulin resistance-associated health conditions. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor proteins that regulate gene expression. In order to investigate the role of PPARs in the pathophysiology of PCOS, we conducted a literature review using the MEDLINE and LIVIVO databases and were able to identify 74 relevant studies published between 2003 and 2023. Different study groups reached contradictory conclusions in terms of PPAR expression in PCOS. Interestingly, numerous natural agents were found to represent a novel, potent anti-PCOS treatment alternatives. In conclusion, PPARs seem to play a significant role in PCOS.

引用

页数：17

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