TiF4-catalyzed direct amidation of carboxylic acids and amino acids with amines

被引：4

作者：

Alawaed, Abdulkhaliq A. ^{[1
]}

Ramachandran, P. Veeraraghavan ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 09期

关键词：

CATALYZED N-FORMYLATION; COUPLING REAGENT; AMIDE FORMATION; PEPTIDE; HEXAFLUOROPHOSPHATE; TIF4; BOND;

D O I：

10.1039/d3ob01943h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Unlike other metal fluorides, catalytic titanium tetrafluoride enhances the direct amidation of aromatic and aliphatic carboxylic acids and N-protected amino acids in refluxing toluene. While aromatic acids were converted to amides with 10 mol% of the catalyst within 24 h, aliphatic acids underwent a faster reaction (12 h), with lower catalyst loading (5 mol%). This protocol is equally efficient with alkyl and aryl amines providing a variety of carboxamides and peptides in 60-99% yields.

引用

页码：1915 / 1919

页数：5

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