High rates of anxiety detected in mothers of children with inconclusive cystic fibrosis screening results

Objective: The purpose was to assess postpartum depression, anxiety, and depression in mothers of chil-dren with an inconclusive diagnosis after a positive cystic fibrosis (CF) newborn screening (NBS), known as cystic fibrosis transmembrane conductance regulator (CFTR)-related metabolic syndrome (CRMS) or CF screen positive, inconclusive diagnosis (CFSPID). There is limited information on the prognosis and on the impact of this designation on maternal mental health.Methods: Mothers of children with CRMS/CFSPID and CF identified by NBS were recruited from two centers in California. Maternal mental health was assessed using measures of depression, anxiety, and a scripted interview. Descriptive statistics and multivariate logistic regression were applied for data report -ing.Results: A total of 109 mothers were recruited: CF: 51, CRMS/CFSPID: 58. Mothers from both groups showed higher rates of depression and anxiety symptoms than women in the general population. CRMS/CFSPID and CF mothers had no significant difference on their self-reported symptoms of anxiety and depression after adjusting for potential confounders. Mothers equally reported that their child's diag-nosis had a negative impact, and that genetic counseling had a positive impact on their emotional health.Conclusions: CF and CRMS/CFSPID diagnoses impact maternal mental health similarly. Uncertain progno-sis of CRMS/CFSPID likely contributed to the negative mental health impact. Providers should consider conducting mental health screening for every mother of a child with CRMS/CFSPID, in addition to the recommended mental health screening for mothers of children with CF. Genetic counseling has potential to mitigate emotional stress on these families.& COPY; 2022 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.