Recent updates on thienopyrimidine derivatives as anticancer agents

被引：24

作者：

Sayed, Menna Tallah M. ^{[1
]}

Hassan, Rasha A. A. ^{[1
]}

Halim, Peter A. A. ^{[1
]}

El-Ansary, Afaf K. K. ^{[1
]}

机构：

[1] Cairo Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Cairo 11562, Egypt

来源：

MEDICINAL CHEMISTRY RESEARCH | 2023年 / 32卷 / 04期

关键词：

Thienopyrimidine; Synthesis; Anticancer agents; Enzyme inhibition; GROWTH-FACTOR RECEPTOR; CELL-CYCLE PROFILE; B-RAF INHIBITORS; BIOLOGICAL EVALUATION; BREAST-CANCER; EFFICIENT SYNTHESIS; EGFR INHIBITORS; DESIGN; STRATEGIES; THERAPY;

D O I：

10.1007/s00044-023-03040-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Thienopyrimidine derivatives hold a unique place between fused pyrimidine compounds. They are important and widely represented in medicinal chemistry as they are structural analogs of purines. Thienopyrimidine derivatives have various biological activities. The current review discusses different synthetic methods for the preparation of heterocyclic thienopyrimidine derivatives. It also highlights the most recent research on the anticancer effects of thienopyrimidines through the inhibition of various enzymes and pathways, which was published within the last 9 years. [GRAPHICS] .

引用

页码：659 / 681

页数：23

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