Temporal Muscle Thickness Correlates with Sarcopenia in Parkinson's Disease

被引:7
|
作者
Peball, Marina [1 ]
Valent, Dora [1 ]
Grossauer, Anna [1 ]
Marini, Kathrin [1 ]
Ellmerer, Philipp [1 ]
Wallnoefer, Jonas [1 ]
Krismer, Florian [1 ]
Djamshidian, Atbin [1 ]
Seppi, Klaus [1 ]
Heim, Beatrice [1 ]
机构
[1] Med Univ Innsbruck, Dept Neurol, Innsbruck, Austria
关键词
Temporal muscle thickness; sarcopenia; Parkinson's disease; frailty; biomarker; FRAILTY; PREVALENCE; SCALE;
D O I
10.3233/JPD-225108
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Sarcopenia is characterized by a progressive loss of muscle mass, strength, and function resulting in adverse health outcomes. Current assessment strategies are bothersome and means to simplify the diagnosis are an unmet medical need in Parkinson's disease (PD). Objective: To evaluate temporal muscle thickness (TMT) obtained on routine cranial MRI as a surrogate marker of sarcopenia in PD patients. Methods: We correlated TMT from axial non-contrast-enhanced T1-weighted sequences of MRI close (+/- 12 months) to an outpatient visit including sarcopenia (EWGSOP1, EWGSOP2, SARC-F), frailty (Fried's criteria, clinical frailty scale), and disease characteristics of Parkinson's patients (Hoehn and Yahr-scale, Movement Disorder Society-Unified Parkinson's Disease Rating Scale, quality of life with the Parkinson's Disease Questionnaire-8) assessments. Results: Cranial MRI was available in 32 patients with a mean age of 73.56 +/- 5.14 years, mean disease duration of 11.46 +/- 5.66 years, and median Hoehn and Yahr stage of 2.5. The mean TMT was 7.49 +/- 2.76 (7.15) mm. Mean TMT was significantly associated with sarcopenia (EWGSOP2, p = 0.018; EWGSOP1, p = 0.023) and frailty status (physical phenotype; p = 0.045). Moreover, there were significant moderate to strong correlations between TMT measurement and appendicular skeletal muscle mass index (r: 0.437, p = 0.012), as well as handgrip strength (r: 0.561, p < 0.001). Conclusion: Reduced TMT seems to be a promising surrogate marker for sarcopenia (EWGSOP2) and muscle strength in this pilot study in PD patients.
引用
收藏
页码:341 / 350
页数:10
相关论文
共 50 条
  • [41] CORTICAL THICKNESS CORRELATES OF WORKING MEMORY CAPACITY IN HEALTHY YOUNGER AND OLDER ADULTS AND IN PARKINSON'S DISEASE
    Valle-Inclan, Fernando
    Lee, Eun-Young
    Li, Dawei
    Cowan, Nelson
    Ricker, Timothy J.
    Hackley, Steven A.
    PSYCHOPHYSIOLOGY, 2013, 50 : S57 - S57
  • [42] Is Dysphagia in Older Patients with Parkinson's Disease Associated With Sarcopenia?
    Umay, Ebru
    Yigman, Z. A.
    Ozturk, E. A.
    Gundogdu, I.
    Kocer, B. G.
    JOURNAL OF NUTRITION HEALTH & AGING, 2021, 25 (06): : 742 - 747
  • [43] Muscle sounds in Parkinson's disease
    Brown, P
    LANCET, 1997, 349 (9051): : 533 - 535
  • [44] Muscle Synergies in Parkinson's Disease
    Mileti, Ilaria
    Zampogna, Alessandro
    Santuz, Alessandro
    Asci, Francesco
    Del Prete, Zaccaria
    Arampatzis, Adamantios
    Palermo, Eduardo
    Suppa, Antonio
    SENSORS, 2020, 20 (11) : 1 - 21
  • [45] Does the thickness of temporal muscle indicate sarcopenia and functional outcome in older patients with acute stroke?
    Ongun, Nedim
    IDEGGYOGYASZATI SZEMLE-CLINICAL NEUROSCIENCE, 2024, 77 (11-12):
  • [46] Temporal Muscle Thickness and Sarcopenia Components in Healthy Adults, Validated through Allgeun Diagnostic Tool
    Park, Kang Min
    Lee, Ho-Joon
    Park, Bong Soo
    Wi, Jin-Hong
    Kwon, Yong-Uk
    Lee, Won Hee
    Lee, Dong Ah
    Kim, Jinseung
    HEALTHCARE, 2024, 12 (10)
  • [47] Abnormal somatosensory temporal discrimination in Parkinson's disease: Pathophysiological correlates and role in motor control deficits
    Lee, Myung Sik
    Lee, Myung Jun
    Conte, Antonella
    Berardelli, Alfredo
    CLINICAL NEUROPHYSIOLOGY, 2018, 129 (02) : 442 - 447
  • [48] Temporal stability of gait in Parkinson's disease
    Morris, ME
    Matyas, TA
    Iansek, R
    Summers, JJ
    PHYSICAL THERAPY, 1996, 76 (07): : 763 - 777
  • [49] Auditory temporal processing in Parkinson's disease
    Guehl, Dominique
    Burbaud, Pierre
    Lorenzi, Christian
    Ramos, Christophe
    Bioulac, Bernard
    Semal, Catherine
    Demany, Laurent
    NEUROPSYCHOLOGIA, 2008, 46 (09) : 2326 - 2335
  • [50] Somatosensory temporal discrimination in Parkinson's disease
    Karakus, A.
    Tokcaer, A. B.
    MOVEMENT DISORDERS, 2013, 28 : S87 - S87