Nectin-4 has emerged as a compelling target for breast cancer

被引:1
|
作者
Wang, Hui [1 ]
Sun, Dejuan [1 ]
Chen, Jinxia [1 ]
Li, Hua [1 ,2 ,3 ]
Chen, Lixia [1 ]
机构
[1] Shenyang Pharmaceut Univ, Wuya Coll Innovat, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China
[2] Fujian Univ Tradit Chinese Med, Inst Struct Pharmacol, Coll Pharm, Fuzhou 350122, Peoples R China
[3] Fujian Univ Tradit Chinese Med, Coll Pharm, TCM Chem Biol, Fuzhou 350122, Peoples R China
基金
中国国家自然科学基金;
关键词
Nectin-4; Breast cancer; Biomarkers; Therapeutic strategies; TOLL-LIKE RECEPTORS; MEASLES-VIRUS; URSOLIC ACID; PROMISING CANDIDATE; ENFORTUMAB VEDOTIN; PROLACTIN RECEPTOR; SOLID TUMORS; T-CELLS; EXPRESSION; FUTURE;
D O I
10.1016/j.ejphar.2023.176129
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The incidence of breast cancer in women has increased year by year, becoming one of the most common malignant tumors in females worldwide. Most patients can be treated with surgery and endocrine drugs, but there are still some patients who lack effective treatment, such as triple-negative breast cancer (TNBC). Nectin-4, a protein encoded by poliovirus receptor-associated protein 4, is a Ca2+-independent immunoglobulin-like protein. It is mainly involved in the adhesion between cells. In recent years, studies have found that Nectin-4 is overexpressed in breast cancer and several other malignancies. Otherwise, several monoclonal antibodies and inhibitors targeting Nectin-4 have shown prosperous outcomes, so Nectin-4 has great potential to be a therapeutic target for breast cancer. The present review systematically describes the significance of Nectin-4 in each aspect of breast cancer, as well as the molecular mechanisms of these aspects mediated by Nectin-4. We further highlight ongoing or proposed therapeutic strategies for breast cancer specific to Nectin-4.
引用
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页数:13
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