A preliminary investigation of the clinical and cognitive correlates of circulating vitamin D in bipolar disorder

被引:1
|
作者
Van Rheenen, Tamsyn E. [1 ,2 ]
Ringin, Elysha [1 ]
Karantonis, James A. [1 ]
Furlong, Lisa [1 ]
Bozaoglu, Kiymet [3 ,4 ]
Rossell, Susan L. [2 ,5 ]
Berk, Michael [6 ,7 ,8 ]
Balanza-Martinez, Vicent [1 ,9 ]
机构
[1] Univ Melbourne, Melbourne Neuropsychiat Ctr, Dept Psychiat, Melbourne, Australia
[2] Swinburne Univ, Ctr Mental Hlth, Sch Hlth Sci, Melbourne, Australia
[3] Murdoch Childrens Res Inst, Bruce Lefroy Ctr Genet Hlth Res, Melbourne, Vic, Australia
[4] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia
[5] St Vincents Hosp, Dept Psychiat, Melbourne, Vic, Australia
[6] Deakin Univ, Inst Mental & Phys Hlth & Clin Translat, Barwon Hlth, Geelong, Vic, Australia
[7] Univ Melbourne, Dept Psychiat, Melbourne, Australia
[8] Orygen Youth Hlth, Melbourne, Australia
[9] Univ Valencia, Dept Med, Teaching Unit Psychiat & Psychol Med, CIBERSAM, Valencia, Spain
关键词
25-hydroxyvitamin D; Global cognition; Mood disorders; Illness duration; Seasonal mood pattern; D DEFICIENCY; HYPOVITAMINOSIS D; D SUPPLEMENTATION; D INSUFFICIENCY; DEPRESSION; ADULTS; MANIA; METAANALYSIS; PREVALENCE; HYPOTHESIS;
D O I
10.1016/j.psychres.2022.115013
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The role that vitamin D plays in the cognitive and clinical characteristics of bipolar disorder (BD) is unclear. We examined differences in the levels and deficiency status of vitamin D in an Australian sample of BD patients compared to healthy controls; and determined the extent to which vitamin D is associated with clinical variables and cognitive function in the sample. 22 healthy controls and 55 stable outpatients with a diagnosis of BD and low-grade mood symptomatology provided a sample of blood and completed cognitive tests and clinical measures. Plasma concentrations of 25-hydroxyvitamin D (vitamin D) were assayed and used to segregate participants into subgroups with sufficient or deficient levels of vitamin D. Subgroups were then compared in terms of global cognition and a range of sociodemographic and clinical factors (number of past mood episodes, illness duration, seasonal mood pattern, mood symptom severity), while mean levels of vitamin D were compared between patients and controls. Although almost 27% of the current sample were vitamin D deficient, no significant differences in mean vitamin D levels or the prevalence of vitamin D deficiency were evident between BD patients and controls. Vitamin D was not associated with global cognition in either patients or controls, nor any of the clinical measures assessed in the study.In conclusion, we observed no difference in the vitamin D levels and deficiency status of an Australian sample of healthy individuals and BD patients with low grade mood symptomatology compared to controls. Clinical symptoms and global cognition also appear to be independent of vitamin D levels in BD.
引用
收藏
页数:7
相关论文
共 50 条
  • [11] Brain imaging correlates of cognitive dysfunctions in bipolar disorder
    Vieta, E
    Benabarre, A
    Martínez-Arán, A
    BIPOLAR DISORDERS, 2004, 6 : 19 - 19
  • [12] Clinical correlates of cardiac conduction in bipolar disorder
    Prieto, Miguel
    Carocca, Alex
    Diaz, Javiera
    Hidalgo, Alicia
    San Martin, Pamela
    Nuno, Mariana
    de Leon, Ana
    Veas, Nicolas
    Rodriguez, Jorge
    Sanchez, Raul
    Fullerton, Claudio
    Castillo, Alejandra
    Cuellar-Barboza, Alfredo
    Biernacka, Joanna
    Frye, Mark
    BIPOLAR DISORDERS, 2021, 23 : 100 - 101
  • [13] Clinical correlates of insulin resistance in bipolar disorder
    Miola, Alessandro
    Cuellar-Barboza, Alfredo
    McElroy, Susan
    BIPOLAR DISORDERS, 2023, 25 : 45 - 45
  • [14] Clinical Correlates of Cardiac Conduction in Bipolar Disorder
    Prieto, M.
    Caroccal, A.
    Fullertoni, C.
    Hidalgo, A.
    Diaz, J.
    Martin, P. San
    Godoy, M.
    Nuno, M.
    De Leon, A.
    Rodriguez, J.
    Sanchez, R.
    Batiz, F.
    Castillo, A.
    Cuellar-Barboza, A.
    Biernacka, J.
    Frye, M.
    EUROPEAN PSYCHIATRY, 2022, 65 : S402 - S402
  • [15] Clinical correlates of trauma spectrum and bipolar disorder
    Santucci, Aurora
    Bolognesi, Simone
    Goracci, Arianna
    Piccione, Serena
    Taddeucci, Costanza
    Laurenzi, Pier Francesco
    Fagiolini, Andrea
    JOURNAL OF PSYCHOPATHOLOGY, 2020, 26 (01): : 21 - 27
  • [16] Clinical correlates of therapeutic response in bipolar disorder
    Bowden, CL
    JOURNAL OF AFFECTIVE DISORDERS, 2001, 67 (1-3) : 257 - 265
  • [17] The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls
    Leser, Bernadette
    Dalkner, Nina
    Tmava-Berisha, Adelina
    Fellendorf, Frederike T.
    Unterrainer, Human-Friedrich
    Stross, Tatjana
    Maget, Alexander
    Platzer, Martina
    Bengesser, Susanne A.
    Haussl, Alfred
    Zwigl, Ina
    Birner, Armin
    Queissner, Robert
    Stix, Katharina
    Wels, Linda
    Schonthaler, Elena M. D.
    Lenger, Melanie
    Schwerdtfeger, Andreas R.
    Zelzer, Sieglinde
    Herrmann, Markus
    Reininghaus, Eva Z.
    NUTRIENTS, 2023, 15 (19)
  • [18] Bipolar Disorder and Polysubstance Use Disorder: Sociodemographic and Clinical Correlates
    Aguglia, Andrea
    Natale, Antimo
    Fusar-Poli, Laura
    Amerio, Andrea
    Bruno, Edoardo
    Placenti, Valeria
    Vai, Eleonora
    Costanza, Alessandra
    Serafini, Gianluca
    Aguglia, Eugenio
    Amore, Mario
    FRONTIERS IN PSYCHIATRY, 2022, 13
  • [19] Examining the clinical correlates of conduct disorder in youth with bipolar disorder
    Woodward, Diana
    Wilens, Timothy E.
    Yule, Amy M.
    DiSalvo, Maura
    Taubin, Daria
    Berger, Amy
    Stone, Mira
    Wozniak, Janet
    Burke, Colin
    Biederman, Joseph
    JOURNAL OF AFFECTIVE DISORDERS, 2023, 329 : 300 - 306
  • [20] Bipolar disorder vulnerability: The vitamin D path
    Naifar, Manel
    Bouali, Manel Maalej
    Guidara, Wassim
    Ellouze, Ahmed Slim
    Jmal, Khalil
    Omri, Sana
    Messedi, Meriam
    Zouari, Lobna
    Elleuch, Aida
    Maalej, Mohamed
    Chaabouni, Khansa
    Charfi, Nada
    Turki, Mouna
    Jihene, Ben Thabet
    Ayadi, Fatma
    CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2020, 65 (03): : 184 - 192