The long and short: Non-coding RNAs in the mammalian inner ear

被引:7
|
作者
Koffler-Brill, Tal [1 ]
Noy, Yael
Avraham, Karen B.
机构
[1] Tel Aviv Univ, Fac Med, Dept Human Mol Genet & Biochem, IL-6997801 Tel Aviv, Israel
基金
美国国家卫生研究院; 以色列科学基金会;
关键词
Non-coding rna; Microrna; Long non-coding rna; Inner ear; Cochlea; Hearing; Deafness; MITOCHONDRIAL RIBOSOMAL-RNA; HAIR CELL APOPTOSIS; GENE-EXPRESSION; SMALL NUCLEAR; BREAST-CANCER; X-CHROMOSOME; HEARING-LOSS; SNORNA U50; MATURATION; MUTATION;
D O I
10.1016/j.heares.2022.108666
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
Non-coding RNAs (ncRNAs) play a critical role in the entire body, and their mis-regulation is often as-sociated with disease. In parallel with the advances in high-throughput sequencing technologies, there is a great deal of focus on this broad class of RNAs. Although these molecules are not translated into proteins, they are now well established as significant regulatory components in many biological path-ways and pathological conditions. ncRNAs can be roughly divided into two main sub-groups based on the length of the transcript, with both the small and long non-coding RNAs having diverse regulatory functions. The smaller length group includes ribosomal RNAs (rRNA), transfer RNAs (tRNA), small nuclear RNAs (snRNA), small nucleolar RNAs (snoRNA), microRNAs (miRNA), small interfering RNAs (siRNA), and PIWI-associated RNAs (piRNA). The longer length group includes linear long non-coding RNAs (lncRNA) and circular RNAs (circRNA). This review is designed to present the different classes of small and long ncRNA molecules and describe some of their known roles in physiological and pathological conditions, as well as methods used to assess the validity and function of miRNAs and lncRNAs, with a focus on their role and functions in the inner ear, hearing and deafness.(c) 2022 Published by Elsevier B.V.
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收藏
页数:11
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