Surgery in the Era of Immunotherapy for Advanced Head and Neck Non-melanoma Skin Cancer

被引:2
|
作者
Lin, Alice [1 ]
Schmalbach, Cecelia E. [2 ,3 ]
机构
[1] Kaiser Permanente Sch Med, Dept Otolaryngol Head & Neck Surg, Pasadena, CA USA
[2] Fox Chase Canc Ctr, Dept Surg Oncol, Philadelphia, PA 19111 USA
[3] Temple Univ, Dept Otolaryngol Head & Neck Surg, Lewis Katz Sch Med, Philadelphia, PA 19122 USA
关键词
Surgery; Immunotherapy; Basal cell carcinoma; Squamous cell carcinoma; Merkel cell carcinoma; Hedgehog inhibitor; PD-1; inhibitor; BASAL-CELL CARCINOMA; SURGICAL MARGINS; INHIBITORS; EXCISION;
D O I
10.1007/s11912-023-01391-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose of ReviewSurgery remains the mainstay of treatment for non-melanoma skin cancer (NMSC). Immunotherapy (IO) has emerged as an alternative option. This review provides a contemporary summary of how to incorporate IO into the management of advanced NMSC. Evidence-based outcomes and recent clinical trials are provided with emphasis on the three most common NMSC diagnoses: cutaneous squamous cell carcinoma (cSCC), basal cell carcinoma (BCC), and merkel cell carcinoma (MCC).Recent FindingsSurgical resection while preserving form and function remains the standard of care for the majority of NMSCs. In recalcitrant cases failing traditional surgery and/or primary radiation, patient ineligible for such treatments, or unresectable disease, IO has emerged as a promising alternative. In the majority of cases, it is a supplanting primary chemotherapy.Surgery remains the standard of care for NMSC. Immunotherapy has emerged as an alternative option for non-surgical candidates and as a neoadjuvant means to minimize morbidity.
引用
收藏
页码:735 / 742
页数:8
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