Intraoperative slow-release dexamethasone intravitreal implant (Ozurdex) in epiretinal membrane peeling surgery: a prospective randomized controlled trial

被引:1
|
作者
Li, Siying [1 ]
Zeng, Qiaozhu [1 ]
Zhu, Li [1 ]
Liu, Wenbo [1 ]
Li, Yujing [1 ]
Li, Jiarui [1 ]
Li, Xiaoxin [1 ]
Zhao, Mingwei [1 ]
Qu, Jinfeng [1 ]
机构
[1] Peking Univ, Peking Univ Hlth Sci Ctr, Eye Dis & Optometry Inst, Coll Optometry,Dept Ophthalmol,Beijing Key Lab Dia, Beijing, Peoples R China
基金
国家重点研发计划; 北京市自然科学基金;
关键词
epiretinal membrane; pars plana vitrectomy; Ozurdex; central retinal thickness; best-corrected visual acuity; MACULAR EDEMA; VISUAL-ACUITY; VITRECTOMY; OUTCOMES; REMOVAL; PUCKER;
D O I
10.3389/fphar.2023.1219861
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Purpose: This study aimed to determine the efficacy of the dexamethasone (DEX) intravitreal implant for the regression of macular edema and the improvement of best-corrected visual acuity (BCVA) after the removal of idiopathic epiretinal membrane (ERM).Methods: This prospective randomized controlled trial recruited 81 patients with idiopathic ERM. These patients all underwent 25-gauge pars plana vitrectomy combined with ERM and internal limiting membrane peeling surgery. Among them, 41 eyes in the DEX group received additional DEX implants and 40 in the non-DEX group did not. Outcomes including central retinal thickness (CRT), BCVA, and intraocular pressure were measured 1 and 3 months after surgery.Results: The DEX group had thinner CRTs compared to the non-DEX group at 1 month postoperatively (p <0.05), but did not differ significantly at the 1-week and 3-month follow-up visits (p = 0.109 and p = 0.417, respectively). There were no statistical differences with respect to BCVA (p = 0.499, 0.309, 0.246, and 0.517, respectively) and intraocular pressure (p = 0.556, 0.639, 0.741, and 0.517, respectively) between the two groups at each point of follow-up visits.Conclusion: DEX accelerated the reduction of CRT at 1 month after surgery. However, no evidence of further anatomical (CRT) or functional (BCVA) benefits using DEX was observed at 3 months.
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页数:8
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