Postoperative adjuvant radiotherapy for patients with upper tract urothelial carcinoma (UTUC) who underwent kidney-sparing surgery (KSS): a single-center study

被引:0
|
作者
Guan, Hui [1 ]
Wang, Guangyu [1 ]
Wang, Weiping [1 ]
Zhou, Yuncan [1 ]
Liu, Zhikai [1 ]
Hou, Xiaorong [1 ]
Yan, Junfang [1 ]
Sun, Shuai [1 ]
Hu, Ke [1 ]
Zhao, Jing [2 ]
机构
[1] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Radiat Oncol, Beijing, Peoples R China
[2] Capital Med Univ, Beijing Shijitan Hosp, Dept Oncol, Beijing, Peoples R China
基金
中国国家自然科学基金;
关键词
Kidney-sparing surgery; Upper tract urothelial carcinoma; Adjuvant radiotherapy; TRANSITIONAL-CELL CARCINOMA; UPPER URINARY-TRACT; SURGICAL-MANAGEMENT; RENAL PELVIS; INTRAVESICAL RECURRENCE; PROGNOSTIC-FACTORS; RISK-FACTORS; SURVIVAL; BLADDER; OUTCOMES;
D O I
10.1186/s13014-023-02303-7
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
ObjectiveThe purpose of this study was to evaluate the efficacy of postoperative adjuvant radiotherapy for patients with upper tract urothelial carcinoma (UTUC) who underwent kidney-sparing surgery (KSS).MethodsWe retrospectively reviewed the clinical records of 31 patients with primary UTUC who underwent kidney-sparing surgery (KSS) and who were treated with adjuvant radiotherapy at our center between October 1998 and May 2017. Statistical analyses were performed with SPSS 23.0. The primary endpoints of this study included overall survival (OS) and local recurrence-free survival (LRFS); the secondary endpoints were disease-free survival (DFS) and treatment-related toxicity.ResultsThe median follow-up was 58.4 months (range, 12.7-185.3 months), and the median local recurrence time was 59.0 months (range, 7.0-185 months). All of the patients completed radiotherapy on schedule, and no grade 3-4 late-stage reaction was observed. The estimated 5-year and 10-year OS, DFS and LRFS rates of the patients were 64.0%, 61.1%, 69.6% and 48.0%, 40.9%, 64.6%, respectively. Univariate analysis showed that age (& chi;2 = 4.224, P = 0.040), R0 resection (& chi;2 = 3.949, P = 0.047), and early stage (I + II) (& chi;2 = 6.515, P = 0.011) were associated with good OS; DFS benefit in early stage patients (& chi;2 = 6.151, P = 0.013) and age<70 years old (& chi;2 = 5.091, P = 0.024). Patients with distal ureteral segments had better LRFS than patients with proximal ureteral cancer (& chi;2 = 5.248, P = 0.022). However, multivariate analysis showed that age was the only factor of OS (& chi;2 = 4.099, P = 0.043).ConclusionAdjuvant radiotherapy is safe and tolerated, and LRFS was superior in middle and distal ureteral cancer than in proximal ureteral cancer.
引用
收藏
页数:7
相关论文
共 50 条
  • [31] Novel classification for upper tract urothelial carcinoma to better risk-stratify patients eligible for kidney sparing strategies: an international collaborative study
    Marcq, G.
    Foerster, B.
    Matin, S. F.
    Spiess, P.
    Bivalacqua, T.
    Wu, W.
    Roupret, M.
    Krabbe, L. M.
    Xylinas, E.
    Mir, C.
    Hendricksen, K.
    Mari, A.
    Egawa, S.
    Briganti, A.
    Moschini, M.
    Mathieu, R.
    Ku, J. H.
    Autorino, R.
    Heidenreich, A.
    Chlosta, P.
    Joniau, S.
    Pycha, A.
    D'andrea, D.
    Shariat, S. F.
    Kassouf, W.
    Wu, Wen-Jeng
    EUROPEAN UROLOGY, 2021, 79 : S1085 - S1086
  • [32] DNA methylation urine biomarkers test (EpiCheck® assay) in the diagnosis of upper tract urothelial carcinoma: Results from a single-center prospective study
    Gallioli, A.
    Fontana, M.
    Boissier, R.
    Territo, A.
    Diana, P.
    Piana, A.
    Martinez, C.
    Sanchez-Puy, A.
    Subiela, J. D.
    Sanguedolce, F.
    Gaya Sopena, J. M.
    Palou, J.
    Breda, A.
    EUROPEAN UROLOGY, 2021, 79 : S1073 - S1073
  • [33] DNA METHYLATION URINE BIOMARKERS TEST (EPICHECK® ASSAY) IN THE DIAGNOSIS OF UPPER TRACT UROTHELIAL CARCINOMA: RESULTS FROM A SINGLE-CENTER PROSPECTIVE STUDY
    Gallioli, Andrea
    Fontana, Matteo
    Boissier, Roman
    Territo, Angelo
    Diana, Pietro
    Piana, Alberto
    Martinez, Christian
    Sanchez-Puy, Antoni
    Daniel Subiela, Jose
    Sanguedolce, Francesco
    Maria Gaya, Josep
    Palou, Joan
    Breda, Alberto
    JOURNAL OF UROLOGY, 2021, 206 : E732 - E732
  • [35] Response to Okeke and Rai:"Adjuvant Single-Dose Upper Urinary Tract Instillation of Mitomycin C After Therapeutic Ureteroscopy for Upper Tract Urothelial Carcinoma: A Single-Center Prospective Nonrandomized Trial" by Gallioli et al.
    Territo, Angelo
    Gallioli, Andrea
    Breda, Alberto
    JOURNAL OF ENDOUROLOGY, 2020, 34 (07) : 793 - 794
  • [36] Epidural Hematoma and Abscess Related to Thoracic Epidural Analgesia: A Single-Center Study of 2,907 Patients Who Underwent Lung Surgery
    Kupersztych-Hagege, Elisa
    Dubuisson, Etienne
    Szekely, Barbara
    Michel-Cherqui, Mireille
    Dreyfus, Jean Francois
    Fischler, Marc
    Le Guen, Morgan
    JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 2017, 31 (02) : 446 - 452
  • [37] Analysis of preoperative nutrition, immunity and inflammation correlation index on the prognosis of upper tract urothelial carcinoma surgical patients: a retrospective single center study
    Ou, Yong
    Zheng, Yang
    Wang, Dong
    Ren, Shangqing
    Liu, Yisha
    BMC SURGERY, 2024, 24 (01)
  • [38] Advanced Age May Not Be an Absolute Contraindication for Radical Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma: A Single-Center Case Series and a Systematic Review with Meta-Analyses
    Ye, Jianjun
    Wu, Qiyou
    Liao, Xinyang
    Zheng, Lei
    Wei, Qiang
    Bao, Yige
    JOURNAL OF CLINICAL MEDICINE, 2023, 12 (23)
  • [39] Radiotherapy as Definitive Treatment of Patients with Primary Vulvar Carcinoma Unfit for Surgery and with Recurrent Vulvar Carcinoma After Primary Radical Surgery: Results of a Retrospective Single-center Study
    Laliscia, Concetta
    Gadducci, Angiolo
    Montrone, Sabrina
    Tana, Roberta
    Morganti, Riccardo
    Fabrini, Maria Grazia
    ANTICANCER RESEARCH, 2016, 36 (01) : 387 - 391
  • [40] Radiotherapy is superior to transarterial chemoembolization as adjuvant therapy after narrow-margin hepatectomy in patients with hepatocellular carcinoma: A single-center prospective randomized study
    Tao Bai
    Zhi-hong Tang
    Xiao-bo Wang
    Jie Chen
    Jia-zhou Ye
    Shao-long Lu
    Meng Wei
    Fei-xiang Wu
    Le-qun Li
    Langenbeck's Archives of Surgery, 409