Synthesis and characterization of bioactive isoxazole and 1,3,4-oxadiazole heterocycle containing scaffolds

被引：1

作者：

Joshi, Kaushik ^{[1
]}

Mahida, Anil ^{[2
]}

Rathod, Jayant ^{[3
]}

机构：

[1] D K V Arts & Sci Coll, Dept Chem, Jamnagar 361008, Gujarat, India

[2] Govt Sci Coll, Dept Chem, Songadh 394670, Gujarat, India

[3] Govt Sci Coll, Dept Chem, Dhanpur 389382, Gujarat, India

来源：

INDIAN JOURNAL OF CHEMISTRY | 2023年 / 62卷 / 03期

关键词：

Isoxazole; 4-oxadiazole; Biheterocycles; Anti; -fungal; -bacterial; PHARMACOLOGICAL EVALUATION; DERIVATIVES; CONVERSION;

D O I：

10.56042/ijc.v62i3.72063

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein we have disclosed the design, synthesis, and study of the biological property of isoxazole and 1,3,4-oxadiazole containing framework. Set of 2-(4-(4-nitrophenoxy)phenyl)-5-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)phenyl)-1,3,4-oxadiazole derivatives have been constructed. Synthesized compounds have been screened for anti-fungal and anti-bacterial activities. Among them, Compound 8a have shown excellent anti-fungal activity against C.albicans fungi. Compound 8b and 8c have exhibited significant anti-bacterial activity with MIC 50 mu g/mL against S. pyogenus and S. aureus pathogens, respectively.

引用

页码：237 / 243

页数：7

共 50 条

[21] Synthesis and characterization of poly(fluorene)-based copolymers containing various 1,3,4-oxadiazole pendants
Sung, HH
Lin, HC
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2005, 43 (13) : 2700 - 2711
[22] Synthesis and characterization of novel poly(arylene ether)s containing 1,3,4-oxadiazole units
Bottino, FA
Di Pasquale, G
Pollicino, A
MACROMOLECULAR RAPID COMMUNICATIONS, 1999, 20 (08) : 405 - 409
[23] Synthesis and characterization of mesogen-jacketed liquid crystalline polymer containing 1,3,4-oxadiazole
Chai Chunpeng
Wang Jing
Fan Xinghe
Chen Xiaofang
Zhou Qifeng
ACTA POLYMERICA SINICA, 2006, (03) : 532 - 535
[24] SYNTHESIS OF NEW 1,3,4-OXADIAZOLE DERIVATIVES
GREKOV, AP
NESYNOV, EP
ZHURNAL OBSHCHEI KHIMII, 1961, 31 (04): : 1122 - &
[25] Improved synthesis and characterisation of 1,3,4-oxadiazole
Aitken, Kati M.
Aitken, R. Alan
ARKIVOC, 2012, : 75 - 79
[26] REVIEW OF SYNTHESIS OF 1,3,4-OXADIAZOLE DERIVATIVES
Patel, Kinjal D.
Prajapati, Shraddha M.
Panchal, Shyamali N.
Patel, Hitesh D.
SYNTHETIC COMMUNICATIONS, 2014, 44 (13) : 1859 - 1875
[27] Synthesis of substituted 1,3,4-oxadiazole derivatives
V. Mickevičius
R. Vaickelionienė
B. Sapijanskaitė
Chemistry of Heterocyclic Compounds, 2009, 45 : 215 - 218
[28] SYNTHESIS OF NEW DERIVATIVES OF 1,3,4-OXADIAZOLE
GREKOV, AP
NESYNOV, EP
JOURNAL OF GENERAL CHEMISTRY USSR, 1961, 31 (04): : 1037 - &
[29] SYNTHESIS OF SUBSTITUTED 1,3,4-OXADIAZOLE DERIVATIVES
Mickevicius, V.
Vaickelioniene, R.
Sapijanskaite, B.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2009, 45 (02) : 215 - 218
[30] Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs
Bhat, K., I
Sufeera, K.
Kumar, Chaitanya Sunil P.
JOURNAL OF YOUNG PHARMACISTS, 2011, 3 (04) : 310 - 314

← 1 2 3 4 5 →