Postoperative pelvic irradiation and vaginal brachytherapy in stage II endometrial cancer

Aim: Stage 2 endometrial cancer is a heterogeneous disease and has a low incidence. The aim of this study is to examine the oncological results in patients with stage 2 endometrial cancer who received pelvic radiotherapy and vaginal brachytherapy (VBT). Material and Methods: Between 2000-2020, all operated eighty patients with stage 2 endometrial cancer were included in the study. Patients were analyzed in terms of baseline characteristics, adjuvant radiation (RT) planning modality, intracavitary VBT, chemotherapy (CT), local relapse, distant failure, overall survival (OS), and disease-free survival (DFS).Results: At the end of a median follow-up of 82 months, none of the patients who underwent pelvic external RT and VBT had vaginal/pelvic failure. It was observed that there was a 13-fold increase in the risk of mortality in patients aged 60 years and older (HR=13,2 ; 95% CI=1.89-92.07, p=0.09 ). The 5-and 10-year OS rates were 92% and 86%, 5 and 10-year DFS rates were 94% and 91%, respectively.Discussion: In the presence of poor prognostic factors in stage 2 endometrial cancer, pelvic external RT and VBT is an effective adjuvant treatment methods with excellent oncological results.