Role of RUNX2 in breast cancer development and drug resistance (Review)

被引：4
|
作者：
Si, Wentao [1 ]
Kan, Chen [1 ]
Zhang, Leisheng [2 ,3 ,4 ,6 ]
Li, Feifei [1 ,5 ]
机构：
[1] Anhui Med Univ, Sch Basic Med Sci, Dept Pathophysiol, Hefei 230032, Anhui, Peoples R China
[2] Gansu Prov Hosp, Key Lab Mol Diagnost & Precis Med Surg Oncol Gansu, Lanzhou 730000, Gansu, Peoples R China
[3] Gansu Prov Hosp, NHC Key Lab Diag & Therapy Gastrointestinal Tumor, Lanzhou 730000, Gansu, Peoples R China
[4] Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab Radiat Technol & Biophys, Hefei 230031, Anhui, Peoples R China
[5] Anhui Med Univ, Sch Basic Med Sci, Dept Pathophysiol, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China
[6] Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab Radiat Technol & Biophys, 350 Shushan Lake Rd, Hefei 230031, Anhui, Peoples R China
来源：
ONCOLOGY LETTERS | 2023年 / 25卷 / 05期
基金：
中国国家自然科学基金;
关键词：
breast cancer; RUNX2; stem cells; drug resistance; regulatory mechanism; STEM-CELL; TRANSCRIPTION FACTOR; BONE METASTASIS; MYELOID-LEUKEMIA; COMPLEX DISEASES; TUMOR; CD44; HETEROGENEITY; PROLIFERATION; ACTIVATION;
D O I：
10.3892/ol.2023.13762
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Breast cancer is the most common malignancy and ranks second among the causes of tumor-associated death in females. The recurrence and drug resistance of breast cancer are intractable due to the presence of breast cancer stem cells (BCSCs), which are adequate to initiate tumor formation and refractory to conventional remedies. Runt-related transcription factor 2 (RUNX2), a pivotal transcription factor in mammary gland and bone development, has also been related to metastatic cancer and BCSCs. State-of-the-art research has indicated the retention of RUNX2 expression in a more invasive subtype of breast cancer, and in particular, triple-negative breast cancer development and drug resistance are associated with estrogen receptor signaling pathways. The present review mainly focused on the latest updates on RUNX2 in BCSCs and their roles in breast cancer progression and drug resistance, providing insight that may aid the development of RUNX2-based diagnostics and treatments for breast cancer in clinical practice.
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页数：11
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