A Pair of Undescribed Alkaloid Enantiomers from Marine Sponge-Derived Fungus Hamigera avellanea and Their Antimicrobial and Cytotoxic Activities

被引:6
|
作者
Minh, Le Thi Hong [1 ]
Anh, Nguyen Mai [1 ]
Huyen, Vu Thi Thu [1 ]
Quyen, Vu Thi [1 ]
Dao, Phi Thi [1 ]
Huong, Doan Thi Mai [1 ,2 ]
Cuong, Pham Van [1 ,2 ]
Tuan, Cao Duc [3 ]
Kiem, Phan Van [1 ,2 ]
Tai, Bui Huu [1 ,2 ]
机构
[1] Inst Marine Biochem, VAST, 18 Hoang Quoc Viet, Hanoi 10072, Vietnam
[2] Grad Univ Sci & Technol, VAST, 18 Hoang Quoc Viet, Hanoi 10072, Vietnam
[3] Hai Phong Univ Med & Pharm, Fac Pharm, 72A Nguyen Binh Khiem, Haiphong 182610, Vietnam
关键词
Hamigera avellanea; hamiavemin A; antibacterial activity; cytotoxic activity; alkaloid; METABOLITES;
D O I
10.1002/cbdv.202301425
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
From marine sponge-associated fungus Hamigera avellanea, thirteen secondary metabolites including a pair of undescribed alkaloid enantiomers (+)-hamiavemin A (4S) (+)-1 and (-)-hamiavemin A (4R) (-)-1. Compound 1 was enantiomers resolved by the Chiralpak AS-3 column, using a hexane/isopropanol mobile phase. Their structures were determined based on extensive analyses of HR-ESI-MS, 1D and 2D NMR spectra. The absolute configuration of (+)-1 and (-)-1 were assigned tentatively by ECD calculations. Among the isolates, compound 6 showed strongest antibacterial activity against Enterococcus faecalis, Staphylococcus aureus, Bacillus cereus, Escherichia coli, Salmonella enterica, and Candida albicans with the MIC values of 2, 2, 16, 32, 64, and 16 mu g/mL, respectively, which were stronger than that of the positive control compound, kanamycin (MIC values ranging from 4 to 128 mu g/mL). In addition, compounds 1, 2, and 9 showed moderate cytotoxic activity against three cancer cell lines, HepG2, A549, and MCF-7 with the IC50 values ranging from 55.35 +/- 1.70 to 83.02 +/- 2.85 mu g/mL.
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页数:6
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