Application of photocrosslinkable hydrogels based on photolithography 3D bioprinting technology in bone tissue engineering

被引：12

作者：

Gao, Jianpeng ^{[1
,2
]}

Liu, Xiao ^{[1
,2
]}

Cheng, Junyao ^{[1
,2
]}

Deng, Junhao ^{[1
]}

Han, Zhenchuan ^{[1
]}

Li, Ming ^{[1
]}

Wang, Xiumei ^{[3
]}

Liu, Jianheng ^{[1
]}

Zhang, Licheng ^{[1
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Dept Orthopaed, Beijing 100036, Peoples R China

[2] Chinese PLA Med Sch, Beijing 100036, Peoples R China

[3] Tsinghua Univ, Sch Mat Sci & Engn, State Key Lab New Ceram & Fine Proc, Key Lab Adv Mat Minist Educ, Beijing 100084, Peoples R China

来源：

REGENERATIVE BIOMATERIALS | 2023年 / 10卷

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

photocrosslinkable hydrogels; photolithography 3D bioprinting; bone tissue engineering; bone regeneration; bone defect; BIOMEDICAL APPLICATIONS; GELATIN; SCAFFOLDS; BIOMATERIALS; STEREOLITHOGRAPHY; REGENERATION; CONSTRUCTS; STRATEGIES; MICELLES; PROPERTY;

D O I：

10.1093/rb/rbad037

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Bone tissue engineering (BTE) has been proven to be an effective method for the treatment of bone defects caused by different musculoskeletal disorders. Photocrosslinkable hydrogels (PCHs) with good biocompatibility and biodegradability can significantly promote the migration, proliferation and differentiation of cells and have been widely used in BTE. Moreover, photolithography 3D bioprinting technology can notably help PCHs-based scaffolds possess a biomimetic structure of natural bone, meeting the structural requirements of bone regeneration. Nanomaterials, cells, drugs and cytokines added into bioinks can enable different functionalization strategies for scaffolds to achieve the desired properties required for BTE. In this review, we demonstrate a brief introduction of the advantages of PCHs and photolithography-based 3D bioprinting technology and summarize their applications in BTE. Finally, the challenges and potential future approaches for bone defects are outlined.

引用

页数：15

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