Physiological Appetite Regulation and Bariatric Surgery

被引:0
|
作者
Ramasamy, Indra [1 ]
机构
[1] Conquest Hosp, Dept Blood Sci, Hastings TN37 7RD, England
关键词
hunger centre; satiety centre; POMC; AgRP/NPY; leptin; incretin; bariatric surgery; obesity therapy; obesity genetics; GLUCAGON-LIKE PEPTIDE-1; GASTRIC-INHIBITORY POLYPEPTIDE; DEPENDENT INSULINOTROPIC POLYPEPTIDE; PROTEIN-COUPLED RECEPTOR; WHITE ADIPOSE-TISSUE; BETA-CELL FUNCTION; FOOD-INTAKE; BILE-ACIDS; SLEEVE GASTRECTOMY; ENERGY HOMEOSTASIS;
D O I
10.3390/jcm13051347
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Obesity remains a common metabolic disorder and a threat to health as it is associated with numerous complications. Lifestyle modifications and caloric restriction can achieve limited weight loss. Bariatric surgery is an effective way of achieving substantial weight loss as well as glycemic control secondary to weight-related type 2 diabetes mellitus. It has been suggested that an anorexigenic gut hormone response following bariatric surgery contributes to weight loss. Understanding the changes in gut hormones and their contribution to weight loss physiology can lead to new therapeutic treatments for weight loss. Two distinct types of neurons in the arcuate hypothalamic nuclei control food intake: proopiomelanocortin neurons activated by the anorexigenic (satiety) hormones and neurons activated by the orexigenic peptides that release neuropeptide Y and agouti-related peptide (hunger centre). The arcuate nucleus of the hypothalamus integrates hormonal inputs from the gut and adipose tissue (the anorexigenic hormones cholecystokinin, polypeptide YY, glucagon-like peptide-1, oxyntomodulin, leptin, and others) and orexigeneic peptides (ghrelin). Replicating the endocrine response to bariatric surgery through pharmacological mimicry holds promise for medical treatment. Obesity has genetic and environmental factors. New advances in genetic testing have identified both monogenic and polygenic obesity-related genes. Understanding the function of genes contributing to obesity will increase insights into the biology of obesity. This review includes the physiology of appetite control, the influence of genetics on obesity, and the changes that occur following bariatric surgery. This has the potential to lead to the development of more subtle, individualised, treatments for obesity.
引用
收藏
页数:33
相关论文
共 50 条
  • [21] Serotonergic regulation of appetite and sodium appetite
    Shin, Yurim
    Kim, Seungjik
    Sohn, Jong-Woo
    JOURNAL OF NEUROENDOCRINOLOGY, 2023, 35 (09)
  • [22] Gut hormone profiles may explain reduced appetite and food intake following bariatric surgery
    Le Roux, CW
    Aylwin, SJB
    Batterham, RL
    Coyle, F
    Borg, CM
    Prasad, V
    Shurey, S
    Ghatei, MA
    Patel, AG
    Bloom, SR
    OBESITY SURGERY, 2005, 15 (07) : 936 - 936
  • [23] The role of bariatric surgery and appetite-related hormones metabolism in obesity treatment: a literature review
    Nykonenko, A. O.
    Haidarzhi, Ye. I.
    Nykonenko, O. S.
    Holovko, M. H.
    Protsenko, A. S.
    ZAPOROZHYE MEDICAL JOURNAL, 2018, (06) : 841 - 847
  • [24] PROSPECTIVE EVALUATION OF APPETITE AND CHANGE IN HUNGER AND WEIGHT LOSS AFTER BARIATRIC SURGERY: PRELIMINARY RESULTS
    Farraj, M.
    Bramnik, Z.
    Arkady, R.
    Nordkin, D.
    Waksman, I.
    OBESITY SURGERY, 2018, 28 : 430 - 430
  • [25] THE PHYSIOLOGICAL CONTROL OF APPETITE IN FISH
    FLETCHER, DJ
    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 1984, 78 (04): : 617 - 628
  • [26] The neurohormonal regulation of energy intake in relation to bariatric surgery for obesity
    Ochner, Christopher N.
    Gibson, Charlisa
    Carnell, Susan
    Dambkowski, Carl
    Geliebter, Allan
    PHYSIOLOGY & BEHAVIOR, 2010, 100 (05) : 549 - 559
  • [27] Regulation of body weight: Lessons learned from bariatric surgery
    Albaugh, Vance L.
    He, Yanlin
    Munzberg, Heike
    Morrison, Christopher D.
    Yu, Sangho
    Berthoud, Hans-Rudolf
    MOLECULAR METABOLISM, 2023, 68
  • [28] DNA methylation of genes regulating appetite and prediction of weight loss after bariatric surgery in obese individuals
    Coppede, F.
    Seghieri, M.
    Stoccoro, A.
    Santini, E.
    Giannini, L.
    Rossi, C.
    Migliore, L.
    Solini, A.
    JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2019, 42 (01) : 37 - 44
  • [29] DNA methylation of genes regulating appetite and prediction of weight loss after bariatric surgery in obese individuals
    F. Coppedè
    M. Seghieri
    A. Stoccoro
    E. Santini
    L. Giannini
    C. Rossi
    L. Migliore
    A. Solini
    Journal of Endocrinological Investigation, 2019, 42 : 37 - 44
  • [30] Appetite regulation and pancreas
    Erlanson-Albertsson, C
    BIOLOGY OF THE PANCREAS IN GROWING ANIMALS, 1999, 28 : 287 - 313