Chimeric transcripts of transposable elements and genes are a source of tumor-specific antigens

被引：0
|
作者：
Shah, Nakul [1 ]
Liang, Yonghao [1 ]
机构：
[1] Washington Univ, Sch Med, St Louis, MO 63110 USA
来源：
NATURE GENETICS | 2023年 / 55卷 / 04期
关键词：
D O I：
10.1038/s41588-023-01349-3(2023)
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Transposable elements (TEs) are transcriptionally activated in cancer and can generate chimeric TE-gene transcripts that are tumor specific. Our pan-cancer study reveals that these transcripts are a source of tumor-specific antigens that are shared across tumor types, bind to HLA and are presented on the extracellular surface of cancer cells appended to membrane-bound proteins.
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页码：538 / 539
页数：2
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