Melanoma and microbiota: Current understanding and future directions

被引：22

作者：

Routy, Bertrand ^{[1
,2
]}

Jackson, Tanisha ^{[3
]}

Mahlmann, Laura ^{[4
]}

Baumgartner, Christina K. ^{[5
]}

Blaser, Martin ^{[6
]}

Byrd, Allyson ^{[7
]}

Corvaia, Nathalie ^{[8
]}

Couts, Kasey ^{[9
]}

Davar, Diwakar ^{[10
,11
]}

Derosa, Lisa ^{[12
,13
,14
]}

Hang, Howard C. ^{[15
,16
]}

Hospers, Geke ^{[17
]}

Isaksen, Morten ^{[18
]}

Kroemer, Guido ^{[19
,20
,21
]}

Malard, Florent ^{[22
]}

Mccoy, Kathy D. ^{[23
]}

Meisel, Marlies ^{[24
,25
]}

Pal, Sumanta ^{[26
]}

Ronai, Ze'ev ^{[27
]}

Segal, Eran ^{[28
]}

Sepich-Poore, Gregory D. ^{[29
,30
]}

Shaikh, Fyza ^{[31
]}

Sweis, Randy F. ^{[32
]}

Trinchieri, Giorgio ^{[33
]}

van den Brink, Marcel ^{[34
,35
,36
]}

Weersma, Rinse K. ^{[37
]}

Whiteson, Katrine ^{[38
]}

Zhao, Liping ^{[39
]}

Mcquade, Jennifer ^{[40
]}

Zarour, Hassane ^{[41
]}

Zitvogel, Laurence ^{[12
,13
,14
,42
]}

机构：

[1] Univ Montreal, Res Ctr CRCHUM, Montreal, PQ H2X 0A9, Canada

[2] Ctr Hosp Univ Montreal CHUM, Dept Med, Hematol Oncol Div, Montreal, PQ H2X 3E4, Canada

[3] Melanoma Res Alliance, 730 15th St NW, Washington, DC 20005 USA

[4] Seerave Fdn, 35-37 New St, St Helier JE2 3RA, Jersey, England

[5] AbbVie Inc, Oncol Discovery Res, N Chicago, IL 60064 USA

[6] Rutgers State Univ, Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USA

[7] Genentech Inc, Dept Canc Immunol, South San Francisco, CA 94080 USA

[8] MaaT Pharm, F-69007 Lyon, France

[9] Univ Colorado, Sch Med, Dept Med, Div Med Oncol, Aurora, CO 80045 USA

[10] Univ Pittsburgh, Dept Med, Pittsburgh, PA 15213 USA

[11] Univ Pittsburgh, UPMC Hillman Canc Ctr, Pittsburgh, PA 15213 USA

[12] Gustave Roussy Canc Ctr, ClinicoBiome, F-94805 Villejuif, France

[13] Univ Paris Saclay, Fac Med, F-94270 Le Kremlin Bicetre, France

[14] Equipe Labellisee Ligue Natl Canc, INSERM, U1015, F-94800 Villejuif, France

[15] Dept Immunol, Scripps Res, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA

[16] Scripps Res, Dept Microbiol & Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA

[17] Univ Groningen, Univ Med Ctr Groningen, Dept Med Oncol, NL-9713 GZ Groningen, Netherlands

[18] Bio Me, N-0349 Oslo, Norway

[19] Sorbonne Univ, Ctr Rech Cordeliers, Equipe Labellisee Ligue Canc, Univ Paris,Inserm,U1138,Inst Univ France, F-75006 Paris, France

[20] Inst Gustave Roussy, Metabol & Cell Biol Platforms, F-94905 Villejuif, France

[21] Hop Europeen Georges Pompidou, AP HP, Inst Canc Paris CARPEM, Dept Biol, F-75015 Paris, France

[22] Sorbonne Univ, Hop St Antoine, AP HP, Ctr Rech St Antoine,INSERM,UMRs938,Serv Hematol Cl, Paris, France

[23] Univ Calgary, Snyder Inst, Cumming Sch Med, Dept Physiol & Pharmacol, Calgary, AB T2N 4N1, Canada

[24] Univ Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA USA

[25] UPMC Hillman Canc Ctr, Canc Immunol & Immunotherapy Program, Pittsburgh, PA USA

[26] City Hope Comprehens Canc Ctr, Dept Med Oncol & Therapeut Res, Duarte, CA 91010 USA

[27] Sanford Burnham Prebys Med Discovery Inst, La Jolla, CA 92037 USA

[28] Weizmann Inst Sci, Comp Sci & Appl Math Dept, 234th Herzel St, IL-7610001 Rehovot, Israel

[29] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

[30] Micronoma Inc, San Diego, CA 92121 USA

[31] Johns Hopkins Sch Med, Dept Oncol, Baltimore, MD 21287 USA

[32] Univ Chicago, Dept Med, Sect Hematol Oncol, Chicago, IL 60637 USA

[33] NCI, NIH, Ctr Canc Res, C, Bethesda, MD 20892 USA

[34] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

[35] Sloan Kettering Inst, Dept Immunol, New York, NY USA

[36] Weill Cornell Med Coll, New York, NY 10065 USA

[37] Univ Groningen, Univ Med Ctr Groningen, Dept Gastroenterol & Hepatol, NL-9713 GZ Groningen, Netherlands

[38] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA

[39] Rutgers CUniv, New Jersey Inst Food Nutr & Hlth, Dept Biochem & Microbiol, New Brunswick, NJ 08901 USA

[40] Univ Texas MD Anderson Canc Ctr, Dept Melanoma Med Oncol, Houston, TX 77030 USA

[41] Univ Pittsburgh, UPMC Hillman Canc Ctr, Pittsburgh, PA 15232 USA

[42] Ctr Clin Invest Biotherapies Canc CICBT, Gustave Roussy, F-94805 Villejuif, France

来源：

CANCER CELL | 2024年 / 42卷 / 01期

关键词：

ANTITUMOR IMMUNITY; FECAL MICROBIOTA; GUT-MICROBIOTA; MEDITERRANEAN DIET; TUMOR MICROBIOME; CANCER RISK; METABOLITES; BACTERIA; IMMUNOTHERAPY; THERAPY;

D O I：

10.1016/j.ccell.2023.12.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Over the last decade, the composition of the gut microbiota has been found to correlate with the outcomes of cancer patients treated with immunotherapy. Accumulating evidence points to the various mechanisms by which intestinal bacteria act on distal tumors and how to harness this complex ecosystem to circumvent primary resistance to immune checkpoint inhibitors. Here, we review the state of the microbiota field in the context of melanoma, the recent breakthroughs in defining microbial modes of action, and how to modulate the microbiota to enhance response to cancer immunotherapy. The host-microbe interaction may be deciphered by the use of "omics"technologies, and will guide patient stratification and the development of microbiota-centered interventions. Efforts needed to advance the field and current gaps of knowledge are also discussed.

引用

页码：16 / 34

页数：19

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