Finite sample t-tests for high-dimensional means

When sample sizes are small, it becomes challenging for an asymptotic test requir-ing diverging sample sizes to maintain an accurate Type I error rate. In this paper, we consider one-sample, two-sample and ANOVA tests for mean vectors when data are high-dimensional but sample sizes are very small. We establish asymptotic t -distributions of the proposed U-statistics, which only require data dimensionality to diverge but sample sizes to be fixed and no less than 3. The proposed tests maintain accurate Type I error rates for a wide range of sample sizes and data dimensionality. Moreover, the tests are nonparametric and can be applied to data which are normally distributed or heavy-tailed. Simulation studies confirm the theoretical results for the tests. We also apply the proposed tests to an fMRI dataset to demonstrate the practical implementation of the methods.(c) 2023 Elsevier Inc. All rights reserved.