Where to mount the IMU? Validation of joint angle kinematics and sensor selection for activities of daily living

We validate the OpenSense framework for IMU-based joint angle estimation and furthermore analyze the framework's ability for sensor selection and optimal positioning during activities of daily living (ADL). Personalized musculoskeletal models were created from anthropometric data of 19 participants. Quaternion coordinates were derived from measured IMU data and served as input to the simulation framework. Six ADLs, involving upper and lower limbs were measured and a total of 26 angles analyzed. We compared the joint kinematics of IMU-based simulations with those of optical marker-based simulations for most important angles per ADL. Additionally, we analyze the influence of sensor count on estimation performance and deviations between joint angles, and derive the best sensor combinations. We report differences in functional range of motion (fRoMD) estimation performance. Results for IMU-based simulations showed MAD, RMSE, and fRoMD of 4.8 degrees, 6.6 degrees, 7.2 degrees for lower limbs and for lower limbs and 9.2 degrees, 11.4 degrees, 13.8 degrees for upper limbs depending on the ADL. Overall, sagittal plane movements (flexion/extension) showed lower median MAD, RMSE, and fRoMD compared to transversal and frontal plane movements (rotations, adduction/abduction). Analysis of sensor selection showed that after three sensors for the lower limbs and four sensors for the complex shoulder joint, the estimation error decreased only marginally. Global optimum (lowest RMSE) was obtained for five to eight sensors depending on the joint angle across all ADLs. The sensor combinations with the minimum count were a subset of the most frequent sensor combinations within a narrowed search space of the 5% lowest error range across all ADLs and participants. Smallest errors were on average < 2 degrees over all joint angles. Our results showed that the open-source OpenSense framework not only serves as a valid tool for realistic representation of joint kinematics and fRoM, but also yields valid results for IMU sensor selection for a comprehensive set of ADLs involving upper and lower limbs. The results can help researchers to determine appropriate sensor positions and sensor configurations without the need for detailed biomechanical knowledge.