Chronicity of repeated blast traumatic brain injury associated increase in oxycodone seeking in rats

被引:6
|
作者
Chiariello, Rachel [1 ,2 ]
McCarthy, Cassandra [1 ,2 ]
Glaeser, Breanna L. [3 ,4 ]
Shah, Alok S. [1 ,2 ]
Budde, Matthew D. [1 ,2 ,4 ]
Stemper, Brian D. [2 ,4 ,5 ,6 ]
Olsen, Christopher M. [1 ,3 ,4 ,7 ]
机构
[1] Med Coll Wisconsin, Dept Neurosurg, Milwaukee, WI USA
[2] Clement J Zablocki Vet Affairs Med Ctr, Milwaukee, WI USA
[3] Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI USA
[4] Med Coll Wisconsin, Neurosci Res Ctr, Milwaukee, WI USA
[5] Marquette Univ, Joint Dept Biomed Engn, Milwaukee, WI USA
[6] Med Coll Wisconsin, Milwaukee, WI USA
[7] Med Coll Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA
关键词
Traumatic brain injury; Opioid; Self-administration; Drug seeking; Extinction; SEX-DIFFERENCES; SUBSTANCE USE; ALCOHOL-CONSUMPTION; COCAINE; FEMALE; RISK; NEUROINFLAMMATION; INCUBATION; DEFICITS; NUCLEUS;
D O I
10.1016/j.bbr.2022.114181
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Numerous epidemiological studies have found co-morbidity between non-severe traumatic brain injury (TBI) and substance misuse in both civilian and military populations. Preclinical studies have also identified this rela-tionship for some misused substances. We have previously demonstrated that repeated blast traumatic brain injury (rbTBI) increased oxycodone seeking without increasing oxycodone self-administration, suggesting that the neurological sequelae of traumatic brain injury can elevate opioid misuse liability. Here, we determined the chronicity of this effect by testing different durations of time between injury and oxycodone self-administration and durations of abstinence. We found that the subchronic (four weeks), but not the acute (three days) or chronic (four months) duration between injury and oxycodone self-administration was associated with increased drug seeking and re-acquisition of self-administration following a 10-day abstinence. Examination of other abstinence durations (two days, four weeks, or four months) revealed no effect of rbTBI on drug seeking at any of the abstinence durations tested. Together, these data indicate that there is a window of vulnerability after TBI when oxycodone self-administration is associated with elevated drug seeking and relapse-related behaviors.
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页数:9
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