To Quiesce or Senesce, That Is the Question for Dedifferentiated Liposarcoma

被引：0
|
作者：
Weiss, Mia C. [1 ,2 ]
Eulo, Vanessa [3 ]
Van Tine, Brian A. [1 ,2 ,4 ,5 ]
机构：
[1] Washington Univ St Louis, Sch Med, Dept Med, Div Med Oncol, St Louis, MO USA
[2] Siteman Canc Ctr, St Louis, MO USA
[3] Univ Alabama Birmingham, Div Hematol & Oncol, Birmingham, AL USA
[4] St Louis Childrens Hosp, Dept Pediat Hematol Oncol, St Louis, MO USA
[5] Washington Univ St Louis, Div Med Oncol, Med & Pediat, 660 South Euclid,Campus Box 8007, St Louis, MO 63110 USA
来源：
CLINICAL CANCER RESEARCH | 2024年 / 30卷 / 04期
关键词：
EFFICACY;
D O I：
10.1158/1078-0432.CCR-23-2787
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Dedifferentiated liposarcoma (DDLPS) has an appealing therapeutic target due to its CDK4 amplification on chromosome 12q. The understanding of geroconversion from quiescent cells to senescent cells defines a patient's response to CDK4 inhibitors. This new observation will inform not only the ongoing phase III clinical trial of abemaciclib, but all future clinical trials in DDLPS. See related article by Gleason et al., p. 703
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收藏
页码：649 / 651
页数：3
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