Effect of the gut microbiota and their metabolites on postoperative intestinal motility and its underlying mechanisms

被引：6
|
作者：
Ma, TianRong [1 ]
Xue, XiaoLei [1 ,3 ]
Tian, Hui [4 ]
Zhou, XinXiu [1 ]
Wang, JunKe [1 ]
Zhao, ZhiWen [1 ]
Wang, MingFei [2 ]
Song, JiYuan [2 ]
Feng, RenXiang [2 ]
Li, Leping [1 ,2 ]
Jing, Changqing [1 ,2 ]
Tian, Feng [1 ,2 ]
机构：
[1] Shandong First Med Univ, Dept Gastrointestinal Surg, Shandong Prov Hosp, Jinan 250021, Peoples R China
[2] Shandong Univ, Shandong Prov Hosp, Cheeloo Coll Med, Dept Gastrointestinal Surg, Jinan 250021, Peoples R China
[3] Shandong First Med Univ, Dept Pharm, Affiliated Hosp 2, Tai An 271000, Peoples R China
[4] Shandong First Med Univ, Liaocheng Peoples Hosp, Dept Gastroenterol, Liaocheng 252000, Peoples R China
来源：
JOURNAL OF TRANSLATIONAL MEDICINE | 2023年 / 21卷 / 01期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
Gut microbiota; Intestinal motility; Metabolites; Postoperative ileus; Probiotics; Review; IRRITABLE-BOWEL-SYNDROME; ENTERIC NERVOUS-SYSTEM; MAST-CELLS; ABDOMINAL-SURGERY; GASTROINTESTINAL MOTILITY; BACTERIAL TRANSLOCATION; INTERSTITIAL-CELLS; ILEUS; ACTIVATION; SEROTONIN;
D O I：
10.1186/s12967-023-04215-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Gut microbiota is closely related to human health and disease because, together with their metabolites, gut microbiota maintain normal intestinal peristalsis. The use of antibiotics or opioid anesthetics, or both, during surgical procedures can lead to dysbiosis and affect intestinal motility; however, the underlying mechanisms are not fully known. This review aims to discuss the effect of gut microbiota and their metabolites on postoperative intestinal motility, focusing on regulating the enteric nervous system, 5-hydroxytryptamine neurotransmitter, and aryl hydrocarbon receptor.
引用
收藏
页数：11
相关论文
共 50 条
  • [11] Determining the association between gut microbiota and its metabolites with higher intestinal Immunoglobulin A response
    Rajput, Mrigendra
    Momin, Tooba
    Singh, Amit
    Banerjee, Surya
    Villasenor, Andrew
    Sheldon, Jessica
    Paudel, Pratikshya
    Rajput, Ravindra
    VETERINARY AND ANIMAL SCIENCE, 2023, 19
  • [12] Potential role of gut microbiota and its metabolites in radiation-induced intestinal damage
    Xin, Jia-Yun
    Wang, Jie
    Ding, Qian-Qian
    Chen, Wei
    Xu, Xi-Ke
    Wei, Xin-Tong
    Lv, Yan-Hui
    Wei, Yan-Ping
    Feng, Yu
    Zu, Xian-Peng
    ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2022, 248
  • [13] The effects of gut microbiota on appetite regulation and the underlying mechanisms
    Yu, Miao
    Yu, Bing
    Chen, Daiwen
    GUT MICROBES, 2024, 16 (01)
  • [14] Effect of mastectomy on gut microbiota and its metabolites in patients with breast cancer
    Fan, Pingming
    Ding, Linwei
    Du, Guankui
    Wei, Changyuan
    FRONTIERS IN MICROBIOLOGY, 2024, 15
  • [15] Gut Microbiota and Its Metabolites in Atherosclerosis Development
    Pieczynska, Magdalena D.
    Yang, Yang
    Petrykowski, S.
    Horbanczuk, Olaf K.
    Atanasov, Atanas G.
    Horbanczuk, Jaroslaw O.
    MOLECULES, 2020, 25 (03):
  • [16] Possible immune mechanisms of gut microbiota and its metabolites in the occurrence and development of immune thrombocytopenia
    Zhu, Gengda
    Yan, Lixiang
    Fang, Lijun
    Fan, Chenyang
    Sun, Hui
    Zhou, Xinli
    Zhang, Yucheng
    Shi, Zhexin
    FRONTIERS IN MICROBIOLOGY, 2024, 15
  • [17] Alterations in gut microbiota and metabolites contribute to postoperative sleep disturbances
    Zhong, Hui
    Jiang, Meiru
    Yuan, Kun
    Sheng, Fang
    Xu, Xiuyun
    Cui, Yong
    Sun, Xijia
    Tan, Wenfei
    ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2025,
  • [18] Evaluating the molecular and genetic mechanisms underlying gut motility disorders
    Chanpong, Atchariya
    Alves, Maria M.
    Bonora, Elena
    De Giorgio, Roberto
    Thapar, Nikhil
    EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 2023, 17 (12) : 1301 - 1312
  • [19] Gut microbiota and its metabolites - molecular mechanisms and management strategies in diabetic kidney disease
    Mao, Zi-Hui
    Gao, Zhong-Xiuzi
    Liu, Dong-Wei
    Liu, Zhang-Suo
    Wu, Peng
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [20] MECHANISMS UNDERLYING STIMULATION OF GOBLET CELL DIFFERENTIATION IN HUMAN INTESTINAL ORGANOIDS BY GUT MICROBIAL METABOLITES OF TRYPTOPHAN
    Borthakur, Alip
    Singhal, Megha
    Haynes, Jennifer
    Sawant, Harshal
    Sundaram, Uma
    GASTROENTEROLOGY, 2023, 164 (06) : S259 - S259
12345