A Novel Composite Endpoint of Toxicity- and Progression-Free Survival after B-Cell Maturation Antigen (BCMA)-Directed Chimeric Antigen Receptor T-Cell Therapy for Relapsed/Refractory Multiple Myeloma

被引:0
|
作者
Mohty, Razan [1 ]
Junmin, Whiting [2 ]
Saha, Aditi [3 ]
Kim, Jongphil [2 ]
Nishihori, Taiga [1 ]
De Avila, Gabriel [4 ]
Corallo, Salvatore [1 ]
Dam, Marian [1 ]
Marin, Jessica [1 ]
Liu, Hien [5 ]
Mokhtari, Sepideh [6 ]
Jain, Michael D. [1 ]
Perna, Fabiana [7 ]
Blue, Brandon [3 ]
Grajales-Cruz, Ariel F. [4 ]
Castaneda, Omar [8 ]
Shain, Kenneth [4 ]
Baz, Rachid [3 ]
Freeman, Ciara Louise L. [8 ]
Alsina, Melissa [5 ]
Locke, Frederick L. [1 ,5 ]
Hansen, Doris K.
Lazaryan, Aleksandr [1 ]
机构
[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat & Cellular Immun, Tampa, FL USA
[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Biostat & Bioinformat, Tampa, FL USA
[3] H Lee Moffitt Canc Ctr & Res Inst, Dept Malignant Hematol, Tampa, FL USA
[4] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA
[5] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA
[6] H Lee Moffitt Canc Ctr & Res Inst, Dept Neurooncol, Tampa, FL USA
[7] H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat & Cellular Immun, Indianapolis, IN USA
[8] H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA
关键词
D O I
10.1182/blood-2023-184406
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:5
相关论文
共 50 条
  • [1] A Novel Composite Endpoint of Toxicity-Free, Progression-Free Survival (TPFS) after CD19-Directed Chimeric Antigen Receptor T-Cell Therapy for Relapsed/Refractory Large B-Cell Lymphoma
    Saha, Aditi
    Mohty, Razan
    Whiting, Junmin
    Flores, Kristen
    Kim, Jongphil
    Nishihori, Taiga
    Chavez, Julio C.
    Khimani, Farhad
    Hansen, Doris K.
    Perna, Fabiana
    Liu, Hien
    Shah, Bijal D.
    Dam, Marian
    Jaffer, Muhammad
    Mokhtari, Sepideh
    Elmariah, Hany
    Faramand, Rawan
    Bachmeier, Christina A.
    Bejanyan, Nelli
    Locke, Frederick L.
    Jain, Michael D.
    Lazaryan, Aleksandr
    BLOOD, 2023, 142
  • [2] Development and Validation of a Prediction Model of Outcome After B-Cell Maturation Antigen-Directed Chimeric Antigen Receptor T-Cell Therapy in Relapsed/Refractory Multiple Myeloma
    Gagelmann, Nico
    Dima, Danai
    Merz, Maximilian
    Hashmi, Hamza
    Ahmed, Nausheen
    Tovar, Natalia
    Oliver-Caldes, Aina
    Stoelzel, Friedrich
    Rathje, Kristin
    Fischer, Luise
    Born, Patrick
    Schaefer, Lisa
    Albici, Anca-Maria
    Schub, Natalie
    Kfir-Erenfeld, Shlomit
    Assayag, Miri
    Asherie, Nathalie
    Wulf, Gerald Georg
    Kharboutli, Soraya
    Mueller, Fabian
    Shune, Leyla
    Davis, James A.
    Anwer, Faiz
    Vucinic, Vladan
    Platzbecker, Uwe
    Ayuk, Francis
    Kroeger, Nicolaus
    Khouri, Jack
    Gurnari, Carmelo
    McGuirk, Joseph
    Stepensky, Polina
    Abdallah, Al-Ola
    de Larrea, Carlos Fernandez
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (14) : 1665 - 1675
  • [3] Quantification of B-cell maturation antigen, a target for novel chimeric antigen receptor T-cell therapy in Myeloma
    Salem, Dalia A.
    Maric, Irina
    Yuan, Constance M.
    Liewehr, David J.
    Venzon, David J.
    Kochenderfer, James
    Stetler-Stevenson, Maryalice
    LEUKEMIA RESEARCH, 2018, 71 : 106 - 111
  • [4] BCMA-targeting chimeric antigen receptor T cell therapy for relapsed and/or refractory multiple myeloma
    Fang, Jiamin
    Zhou, Fuling
    ANNALS OF HEMATOLOGY, 2024, 103 (04) : 1069 - 1083
  • [5] Associations of T-cell fitness prior to B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor T-cell (CART) and bispecific T-cell engager (BiTE) therapies and efficacy/toxicity in relapsed/refractory multiple myeloma (RRMM)
    Theprungsirikul, Poy
    Yu, Mansen
    Rall, Kerri
    Matthews, Martin
    Neparidze, Natalia
    Parker, Terri L.
    Browning, Sabrina
    Anderson, Tara
    Stevens, Erica
    Foss, Francine M.
    Gowda, Lohith
    Pillai, Manoj
    Isufi, Iris
    Seropian, Stuart
    Mirza, Sayeef
    Bar, Noffar
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [6] Updated Results of Ciltacabtagene Autoleucel (Cilta-Cel), a B-Cell Maturation Antigen (BCMA)-Directed Chimeric Antigen Receptor T (CAR-T) Cell Therapy in Relapsed/Refractory Multiple Myeloma (RRMM)
    Usmani, Saad Z.
    Berdeja, Jesus G.
    Madduri, Deepu
    Jakubowiak, Andrzej
    Agha, Mounzer
    Cohen, Adam D.
    Hari, Parameswaran
    Yeh, Tzu-Min
    Olyslager, Yunsi
    Banerjee, Arnob
    Jackson, Carolyn C.
    Allred, Alicia
    Zudaire, Enrique
    Deraedt, William
    Wu, Xiaoling
    Carrasco-Alfonso, Marlene J.
    Akram, Muhammad
    Lin, Yi
    Martin, Thomas
    Jagannath, Sundar
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2021, 21 : S422 - S423
  • [7] Ciltacabtagene autoleucel, a B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T-cell (CAR-T) therapy, in relapsed/refractory multiple myeloma (R/R MM): Updated results from CARTITUDE-1.
    Usmani, Saad Zafar
    Berdeja, Jesus G.
    Madduri, Deepu
    Jakubowiak, Andrzej J.
    Agha, Mounzer E.
    Cohen, Adam D.
    Hari, Parameswaran
    Yeh, Tzu-Min
    Olyslager, Yunsi
    Banerjee, Arnob
    Jackson, Carolyn Chang
    Allred, Alicia Jones
    Zudaire, Enrique
    Deraedt, William
    Wu, Xiaoling
    Carrasco-Alfonso, Marlene
    Akram, Muhammad
    Lin, Yi
    Martin, Thomas G.
    Jagannath, Sundar
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)
  • [8] Current advances in chimeric antigen receptor T-cell therapy for refractory/relapsed multiple myeloma
    Huang, He
    uW, Heng-wei
    Hu, Yong-xian
    JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B, 2020, 21 (01): : 29 - 41
  • [9] Clinical activity of P-BCMA-ALLO1, a B-cell maturation antigen (BCMA) targeted allogeneic chimeric antigen receptor T-cell (CAR-T) therapy, in relapsed refractory multiple myeloma (RRMM) patients (pts) following progression on prior BCMA targeting therapy
    Dholaria, Bhagirathbhai
    Shune, Leyla
    Kin, Andrew
    McArthur, Katherine
    Eskew, Jeff D.
    Martin, Christopher E.
    Haag, Sabrina
    McCaigue, Joanne
    Namini, Hamid
    DePrimo, Sam
    Cranert, Stacey
    Coronella, Julia
    Shedlock, Devon
    Belani, Rajesh
    CANCER RESEARCH, 2024, 84 (07)
  • [10] Subsequent anti-myeloma therapy after maturation antigen (BCMA) chimeric antigen receptor (CAR)-T cell (HDS269B) treatment in patients with relapsed/refractory multiple myeloma
    Chen, Dongjian
    Wang, Xiaoxiang
    Chen, Zhi
    Jiang, Songfu
    Jiang, Hua
    Fu, Weijun
    Xiang, Fang
    Sun, Xuedong
    Du, Juan
    AMERICAN JOURNAL OF HEMATOLOGY, 2022, 97 (12) : E478 - E481