Prospects and challenges of CRISPR/Cas9 gene-editing technology in cancer research

被引：3
|
作者：
Ning, Li [1 ,2 ]
Xi, Jiahui [1 ,2 ]
Zi, Yin [1 ,2 ]
Chen, Min [1 ,2 ]
Zou, Qingjian [1 ,2 ]
Zhou, Xiaoqing [1 ,2 ]
Tang, Chengcheng [1 ,2 ]
机构：
[1] Wuyi Univ, South China Inst Large Anim Models Biomed, Sch Biotechnol & Hlth Sci, Guangdong Prov Key Lab Large Anim Models Biomed, Jiangmen 529000, Peoples R China
[2] Int Healthcare Innovat Inst Jiangmen, Jiangmen, Peoples R China
来源：
CLINICAL GENETICS | 2023年 / 104卷 / 06期
关键词：
cancer; gene-editing; CRISPR/Cas9; gene therapy; immunotherapy; T-CELLS; CAS9; RIBONUCLEOPROTEIN; GENOMIC DNA; DELIVERY; BASE; IDENTIFICATION; BACTERIA; EFFICACY; REPEATS; SYSTEMS;
D O I：
10.1111/cge.14424
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Cancer, one of the leading causes of death, usually commences and progresses as a result of a series of gene mutations and dysregulation of expression. With the development of clustered regularly interspaced palindromic repeat (CRISPR)/Cas9 gene-editing technology, it is possible to edit and then decode the functions of cancer-related gene mutations, markedly advance the research of biological mechanisms and treatment of cancer. This review summarizes the mechanism and development of CRISPR/Cas9 gene-editing technology in recent years and describes its potential application in cancer-related research, such as the establishment of human tumor disease models, gene therapy and immunotherapy. The challenges and future development directions are highlighted to provide a reference for exploring pathological mechanisms and potential treatment protocols of cancer.
引用
收藏
页码：613 / 624
页数：12
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