Gastroenteropancreatic Neuroendocrine Tumor Metastasis to the Heart: Evaluation of Imaging Manifestations

被引:3
|
作者
Wang, Yuxiang [1 ]
Ayoub, Chadi [1 ]
Yang, Aaron F. [1 ]
Sonbol, Mohamad B. [2 ]
Butter, Richard [3 ]
Halfdanarson, Thorvardur R. [4 ]
Arsanjani, Reza [1 ]
Zhu, Wuqiang [1 ]
Yang, Ming [5 ,6 ]
机构
[1] Mayo Clin, Div Cardiovasc Dis, Scottsdale, AZ USA
[2] Mayo Clin, Dept Hematol Oncol, Scottsdale, AZ USA
[3] Mayo Clin, Div Biostat, Scottsdale, AZ USA
[4] Mayo Clin, Dept Med Oncol, Rochester, MN USA
[5] Mayo Clin, Dept Radiol, Scottsdale, AZ USA
[6] Mayo Clin, Dept Radiol, 13400 East Shea Blvd, Scottsdale, AZ 85259 USA
关键词
DISEASE; PET/CT;
D O I
10.1067/j.cpradiol.2022.11.011
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Neuroendocrine tumors (NET) may affect the heart by cardiac metastasis or carcinoid heart disease. NET metastasis to the heart is rare, with limited data characterizing it. We sought to evaluate Ga-68-DOTATATE PET scan imaging features and associated cardiac imaging characteristics where available in those with NET cardiac metastases. Ga-68-DOTATATE positron emission tomography (PET)/CT scans performed on patients with gastroenteropancreatic (GEP) NET at our institution were reviewed for cardiac involvement. Those identified with cardiac metastases had their electronic medical record, transthoracic echocardiogram (TTE) and cardiac magnetic resonance imaging (MRI) reviewed for characterization. From a total of 1426 Ga-68-DOTATATE PET/CT scans performed on patients with GEP-NET, 25 (1.75%) had cardiac uptake consistent with metastasis. Of these, 22 had myocardial metastases (29 distinct myocardial lesions: left ventricle - 16, right ventricle - 6, and ventricular septum -7) and 3 had periradial lymph node involvement only. NET patients with cardiac metastases as identified by DOTATATE scan did not appear to have any hemodynamically significant TTE features, aside from those (2/25) who had concomitant carcinoid heart disease. Of the 14 patients who had available TTE for review, only one with high metastatic cardiac tumor burden had detectable cardiac mass. Of the 6 cases who had available MRI, all had metastatic cardiac lesions seen with excellent correlation with tumor localization on Ga-68-DOTATATE PET scan. Ga-68-DOTATATE PET has excellent capability for the diagnosis of cardiac NET metastasis. Cardiac MRI may provide further anatomic and tissue characterization evaluation. Those with myocardial NET metastases without carcinoid heart disease did not have significant hemodynamic effect based on echocardiographic criteria. (c) 2022 Elsevier Inc. All rights reserved.
引用
收藏
页码:340 / 345
页数:6
相关论文
共 50 条
  • [41] Gastroenteropancreatic neuroendocrine neoplasm - a complex presentation in imaging methods
    Rudnay, Maros
    Batekova, Martina
    Rjaskova, Gabriela
    Dankovcik, Robert
    Lehotska, Viera
    NEUROENDOCRINOLOGY LETTERS, 2021, 42 (03) : 141 - 149
  • [42] Gastroenteropancreatic neuroendocrine neoplasm imaging: standard reporting templates
    Chadwick Barrs
    Malak Itani
    Maria Zulfiqar
    Joyce Mhlanga
    Isaac R. Francis
    Ajaykumar Morani
    Priya Bhosale
    Motoyo Yano
    Amir Iravani
    Abdominal Radiology, 2022, 47 : 3986 - 3992
  • [43] Somatostatin receptors imaging in gastroenteropancreatic neuroendocrine tumors.
    Mura, A
    Lebtahi, R
    de Labriolle-Vaylet, C
    Askienazy, S
    GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE, 1998, 22 (10): : 809 - 818
  • [44] Pulmonary neuroendocrine tumors Pulmonary Manifestations of neuroendocrine tumor
    Kolb, M.
    Boesmueller, H.
    Haap, M.
    Horger, M.
    ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN, 2016, 188 (09): : 819 - 823
  • [45] Correlation of Diffusion weighted MR Imaging and ADC Values of Hepatic Metastasis of Gastrointestinal Stromal and Gastroenteropancreatic Neuroendocrine Tumors
    Aydin, Hasan
    Metin, Melike Rusen
    Kizilgoz, Volkan
    CURRENT MEDICAL IMAGING, 2024, 20
  • [46] Natural history of liver metastasis of gastroenteropancreatic neuroendocrine tumors: Place for chemoembolization
    Proye, C
    WORLD JOURNAL OF SURGERY, 2001, 25 (06) : 685 - 688
  • [47] Natural History of Liver Metastasis of Gastroenteropancreatic Neuroendocrine Tumors: Place for Chemoembolization
    C. Proye
    World Journal of Surgery, 2001, 25 : 685 - 688
  • [48] Comparative Clinical Analysis of Gastroenteropancreatic Neuroendocrine Carcinomas with Liver Metastasis and Primary Hepatic Neuroendocrine Carcinomas
    Qiu, Meng-jun
    Chen, Yao-bing
    Bi, Ning-rui
    Yang, Sheng-li
    He, Xiao-xiao
    Xiong, Zhi-fan
    DISEASE MARKERS, 2018, 2018
  • [49] Gastroenteropancreatic neuroendocrine tumor cancer stem cells: do they exist?
    Enrique Grande
    Jaume Capdevila
    Jorge Barriuso
    Luis Antón-Aparicio
    Daniel Castellano
    Cancer and Metastasis Reviews, 2012, 31 : 47 - 53
  • [50] Gastroenteropancreatic neuroendocrine tumor of the accessory papilla of the duodenum: a case report
    Takagi, Kosei
    Umeda, Yuzo
    Yoshida, Ryuichi
    Yoshida, Kazuhiro
    Yasui, Kazuya
    Sato, Hiroki
    Yagi, Takahito
    Fujiwara, Toshiyoshi
    SURGICAL CASE REPORTS, 2021, 7 (01)