Aberrant MUC Immunohistochemical Expressions in Inflammatory Bowel Diseases

被引：2

作者：

Hamamoto, Yuichiro ^{[1
,3
,5
]}

Kawamura, Michihiro ^{[2
]}

Uchida, Hiroki ^{[2
]}

Takagahara, Kojiro ^{[2
]}

Katori, Chiaki ^{[2
]}

Asai, Hinako ^{[2
]}

Harada, Hiroshi ^{[1
]}

Shimizu, Shigeki ^{[4
]}

Morii, Eiichi ^{[3
]}

Yoshida, Kyotaro ^{[1
,2
]}

机构：

[1] Kinki Cent Hosp, Dept Diagnost Pathol, Itami, Hyogo, Japan

[2] Kinki Cent Hosp, Dept Clin Lab, Itami, Hyogo, Japan

[3] Osaka Univ, Dept Pathol, Grad Sch Med, Suita, Japan

[4] Natl Hosp Org Kinki Chuo Chest Med Ctr, Dept Clin Lab, Kita Ku, Osaka, Japan

[5] Kinki Cent Hosp, Dept Diagnost Pathol, 3-1 Kurumaduka,, Itami, Hyogo 6648533, Japan

来源：

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY | 2023年 / 31卷 / 02期

关键词：

mucin; MUC; ulcerative colitis; crohn disease; ischemic colitis; inflammatory bowel disease; immunohistochemistry; ULCERATIVE-COLITIS; BARRIER;

D O I：

10.1097/PAI.0000000000001096

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Ulcerative colitis (UC) and Crohn disease (CD) are cryptogenic inflammatory bowel diseases that are suggestive of aberrant mucin (MUC) expression; however, their relationship remains unclear. Here, we examined aberrant MUC expression in intestinal samples from UC and CD patients in comparison to samples from patients with ischemic colitis and control groups. To study the expression of MUC1, MUC5AC, and MUC6 in different patient groups, we reviewed the slides stained with hematoxylin and eosin and performed immunohistochemistry. The results revealed that MUC1 was expressed more in the UC group and MUC6 in the CD group. No significant changes were observed in MUC expression in the ischemic colitis group. Overall, we demonstrated changes in MUC expression in UC and CD, which can help in the diagnosis and early clinical management of UC and CD.

引用

页码：107 / 112

页数：6

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