Ruthenium-Catalyzed C-H Arylation of Aromatic Acids with ortho-Haloaniline To Access Phenanthridinones

被引：4
|
作者：
Luo, Xianglin [1 ]
Shen, Jiayi [1 ]
Jiang, Huanfeng [1 ]
Huang, Liangbin [1 ]
机构：
[1] South China Univ Technol, Sch Chem & Chem Engn, State Key Lab Pulp & Paper Engn, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Peoples R China
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 14期
基金：
中国国家自然科学基金;
关键词：
N-METHOXYBENZAMIDES; BIOLOGICAL EVALUATION; BENZOIC-ACIDS; ARYL; ARYNES; CARBONYLATION; BENZAMIDES; ARENES; 2-ARYLANILINES; DERIVATIVES;
D O I：
10.1021/acs.orglett.3c04377
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Phenanthridinone is a significant moiety in pharmaceutical and material science; thus, it is highly desirable to develop an efficient and robust method to construct phenanthridinone from readily available starting materials. Herein, we report a Ru-catalyzed C-H arylation of aromatic carboxylic acids with ortho-haloanilines, followed by intramolecular dehydration to afford phenanthridinones in high yields. [GRAPHICS]
引用
收藏
页码：2883 / 2887
页数：5
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