Diastereoselective synthesis of trans-2,3-dihydroindoles via formal [4+1] annulation reactions of a sulfonium ylide

被引：3
|
作者：
Jain, Anshul [1 ]
Kumari, Akanksha [1 ]
Metre, Ramesh K. [1 ]
Rana, Nirmal K. [1 ]
机构：
[1] Indian Inst Technol Jodhpur, Dept Chem, Jodhpur 342030, India
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 03期
关键词：
CONSTRUCTION; INDOLINES;
D O I：
10.1039/d3ob01793a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have established an in situ generated sulfonium-ylide mediated annulation to construct 2,3-disubstituted-2,3-dihydroindoles. The [4 + 1] annulation approach relied on Michael addition/substitution reactions. These reactions were carried out at ambient temperature to deliver dihydroindoles with excellent yields and diastereoselectivities. Moreover, the versatility of this approach allows for the introduction of various functional groups, enabling further diversification of the dihydroindoles. Also, the cascade approach was broadened to synthesize dihydrobenzofurans.
引用
收藏
页码：621 / 632
页数：12
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