Epidemiological and clinical features of malignant hyperthermia: A scoping review

被引:3
|
作者
Cong, Zhukai [1 ,2 ]
Wan, Tingting [1 ,2 ]
Wang, Jiechu [1 ,2 ]
Feng, Luyang [1 ,2 ]
Cao, Cathy [3 ]
Li, Zhengqian [1 ,2 ]
Wang, Xiaoxiao [4 ]
Han, Yongzheng [1 ,2 ]
Zhou, Yang [1 ,2 ]
Gao, Ya [1 ,2 ]
Zhang, Jing [1 ,2 ]
Qu, Yinyin [1 ,2 ,5 ]
Guo, Xiangyang [1 ,2 ,5 ]
机构
[1] Peking Univ Third Hosp, Dept Anesthesiol, Beijing, Peoples R China
[2] Beijing Ctr Qual Control & lmprovement Clin Anesth, Beijing, Peoples R China
[3] MedStar Washington Hosp Ctr, Dept Anesthesiol, Washington, DC USA
[4] Peking Univ Third Hosp, Res Ctr Clin Epidemiol, Beijing, Peoples R China
[5] Peking Univ Third Hosp, Dept Anesthesiol, 49 North Garden Rd, Beijing 100191, Peoples R China
基金
中国国家自然科学基金;
关键词
clinical features; clinical signs; epidemiology; malignant hyperthermia; risk factors; RETROSPECTIVE COHORT; SUSCEPTIBLE PATIENTS; RYANODINE RECEPTOR; DISCHARGE RECORDS; NEW-YORK; DIAGNOSIS; DANTROLENE; HALOTHANE; CALCIUM; RISK;
D O I
10.1111/cge.14475
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Malignant hyperthermia (MH) is a potentially fatal inherited pharmacogenetic disorder related to pathogenic variants in the RYR1, CACNA1S, or STAC3 genes. Early recognition of the occurrence of MH and prompt medical treatment are indispensable to ensure a positive outcome. The purpose of this study was to provide valuable information for the early identification of MH by summarizing epidemiological and clinical features of MH. This scoping review followed the methodological framework recommended by Arksey and O'Malley. PubMed, Embase, and Web of science databases were searched for studies that evaluated the epidemical and clinical characteristics of MH. A total of 37 studies were included in this review, of which 26 were related to epidemiology and 24 were associated with clinical characteristics. The morbidity of MH varied from 0.18 per 100 000 to 3.9 per 100 000. The mortality was within the range of 0%-18.2%. Identified risk factors included sex, age, disorders associated with MH, and others. The most frequent initial clinical signs included hyperthermia, sinus tachycardia, and hypercarbia. The occurrence of certain signs, such as hypercapnia, delayed first temperature measurement, and peak temperature were associated with poor outcomes. The epidemiological and clinical features of MH varied considerably and some risk factors and typical clinical signs were identified. The main limitation of this review is that the treatment and management strategies were not assessed sufficiently due to limited information. A scoping review was conducted to summarize and analyze the clinical and epidemiological features of malignant hyperthermia according to the latest literature from 2010 to 2021.image
引用
收藏
页码:233 / 242
页数:10
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