Confined assembly of 2D biofilms at the air-water interface for versatile surface biofunctionalization of osteogenic implants

被引：6
|
作者：
Na, Xiaokang [1 ,2 ,3 ]
Liu, Huilong [4 ]
Li, Xuyuan [5 ,6 ,7 ]
Du, Ming [1 ,2 ,3 ]
Wang, Tao [5 ,6 ,7 ]
Zhang, Zunmin [4 ]
Wu, Chao [1 ,2 ,3 ]
机构：
[1] Dalian Polytech Univ, Sch Food Sci & Technol, Dalian 116034, Peoples R China
[2] Dalian Polytech Univ, State Key Lab Marine Food Proc & Safety Control, Dalian 116034, Peoples R China
[3] Dalian Polytech Univ, Liaoning Key Lab Food Nutr & Hlth, Dalian 116034, Peoples R China
[4] Nanjing Tech Univ, Coll Chem Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 211816, Peoples R China
[5] Jiangnan Univ, State Key Lab Food Sci & Resources, Wuxi 214122, Peoples R China
[6] Jiangnan Univ, Natl Engn Res Ctr Cereal Fermentat & Food Biomfg, Wuxi 214122, Peoples R China
[7] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Peoples R China
来源：
NANO TODAY | 2024年 / 54卷
基金：
中国国家自然科学基金;
关键词：
Air-water assembly; Biogenic functionalization; Lactoferrin; Osteo-regenerative biomaterials; Yuba-inspired; CALCIUM-PHOSPHATE; PROTEIN; MACROMOLECULE; NANOSHEETS; TITANIUM;
D O I：
10.1016/j.nantod.2023.102086
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The increasing aging population has created a huge demand for osteogenic implants. In this study, we report a biogenic, scalable, and osteogenic biofilm for in vivo osseointegration. Experimental and simulation studies showed vertical migration and horizontal juxtaposition of lactoferrin (LF) nanoaggregates at the air-water interface, forming 2D biofilms with highly controllable thickness, roughness, and adhesiveness. The inherent biocompatible, antibacterial, and osteogenic properties of LF clearly translated the biofilms into facile coatings for versatile surface biofunctionalization of various implants such as polylactic acid. Specifically, the defective tibiae in rat models receiving such implants featured a 149% increase in bone volume/tissue volume and a 57% increase in the number of bone trabeculae after an 8-week recovery, making the LF-based biofilms the best among the biomolecular osteo-regenerative coatings reported so far. This study provided a compelling example of how the inherent biofunctions of natural proteins can be combined with surface biofunctionalization towards advanced biomedical applications.
引用
收藏
页数：11
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