Longevity of the humoral and cellular responses after SARS-CoV-2 booster vaccinations in immunocompromised patients

被引：3

作者：

Oyaert, Matthijs ^{[1
]}

De Scheerder, Marie-Angelique ^{[2
]}

Van Herrewege, Sophie ^{[2
]}

Laureys, Guy ^{[3
]}

Van Assche, Sofie ^{[3
]}

Cambron, Melissa ^{[4
]}

Naesens, Leslie ^{[5
,6
]}

Hoste, Levi ^{[5
,6
]}

Claes, Karlien ^{[5
,6
]}

Haerynck, Filomeen ^{[5
,6
]}

Kerre, Tessa ^{[7
]}

Van Laecke, Steven ^{[8
]}

Jacques, Peggy ^{[9
]}

Padalko, Elizaveta ^{[1
]}

机构：

[1] Ghent Univ Hosp, Dept Lab Med, Ghent, Belgium

[2] Ghent Univ Hosp, Dept Gen Internal Med, Ghent, Belgium

[3] Ghent Univ Hosp, Dept Neurol, Ghent, Belgium

[4] AZ Sint Jan Brugge Oostende, Dept Neurol, Brugge, Belgium

[5] Ghent Univ Hosp, Dept Internal Med & Paediat, Ghent, Belgium

[6] Univ Ghent, Primary Immunodeficiency Res Lab, Ghent, Belgium

[7] Ghent Univ Hosp, Dept Haematol, Ghent, Belgium

[8] Ghent Univ Hosp, Dept Nephrol, Ghent, Belgium

[9] Ghent Univ Hosp, Dept Rheumatol, Ghent, Belgium

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2024年 / 43卷 / 01期

关键词：

SARS-CoV-2; mRNA vaccine; Immunocompromised patients; VACCINE; PEOPLE; INFECTION; COVID-19; ANTIBODY;

D O I：

10.1007/s10096-023-04701-x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We assessed the humoral and cellular immune responses after two booster mRNA vaccine administrations [BNT162b2 (Pfizer-BioNTech vaccine)] in cohorts of immunocompromised patients (n = 199) and healthy controls (HC) (n = 54). All patients living with HIV (PLWH) and chronic kidney disease (CKD) patients and almost all (98.2%) of the primary immunodeficiency (PID) patients had measurable antibodies 3 and 6 months after administration of the third and fourth vaccine dose, comparable to the HCs. In contrast, only 53.3% and 83.3% of the multiple sclerosis (MS) and rheumatologic patients, respectively, developed a humoral immune response. Cellular immune response was observed in all PLWH after administration of four vaccine doses. In addition, cellular immune response was positive in 89.6%, 97.8%, 73.3% and 96.9% of the PID, MS, rheumatologic and CKD patients, respectively. Unlike the other groups, only the MS patients had a significantly higher cellular immune response compared to the HC group. Administration of additional vaccine doses results in retained or increased humoral and cellular immune response in patients with acquired or inherited immune disorders.

引用

页码：177 / 185

页数：9

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