Risk factors and prognosis for the development of acute kidney injury in patients using colistin in the intensive care unit: A retrospective cohort study

被引:0
|
作者
Deniz, Mustafa [1 ]
Alisik, Murat [2 ]
机构
[1] Izzet Baysal State Hosp, Intens Care Unit, TR-14300 Bolu, Turkiye
[2] Bolu Abant Izzet Baysal Univ, Med Biochem, Bolu, Turkiye
关键词
acute kidney injury; colistin; intensive care unit; multidrug resistance; vasopressors; INDUCED NEPHROTOXICITY; SEPSIS;
D O I
10.1097/MD.0000000000036913
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Colistin, an antibiotic of polymyxin group, has recently been increasingly used in the treatment of multidrug resistant gram-negative bacteria. However, it has serious adverse effects such as acute kidney injury (AKI). We aimed to determine the factors affecting the development of AKI due to colistin, which has serious adverse effects, such as nephrotoxicity and neurotoxicity. We retrospectively analyzed the data of patients who received colistin for multidrug resistant gram-negative sepsis in adult intensive care units between January 2020 and December 2022. Demographic data, blood test results, concomitant drug use, need for renal replacement therapy, and mortality were recorded. Kidney damage was assessed according to the Kidney Disease Improving Global Outcomes criterion. We obtained data from 103 patients, 45 (43.7%) of whom were women. The most common comorbidity was a neurological disorder. Renal damage developed in 59.2% of patients. Renal replacement was required in 50.8% of the patients. Among patients who received colistin, 64.1% died. The use of vasopressors, diuretics, nephrotoxic agents with colistin, advanced age, and hypoalbuminemia were more common in patients with renal injury. Multivariate regression analysis showed that vasopressor use, prior creatinine elevation, and diuretic use were independent risk factors for colistin-induced AKI. Vasoactive agent use, previous kidney injury, and furosemide use were independent risk factors for colistin-induced nephrotoxicity. Considering these factors may be instructive for better monitoring of patients when colistin is required in intensive care units.
引用
收藏
页数:5
相关论文
共 50 条
  • [41] Risk factors for the deterioration of oxygenation ratio in ventilated intensive care unit patients: A retrospective cohort study
    Fick, Ilma W. F.
    Tijdink, Myrthe M.
    Halbertsma, Feico J. J.
    van der Hoeven, Johannes G.
    Pickkers, Peter
    JOURNAL OF CRITICAL CARE, 2010, 25 (01) : 3 - 9
  • [42] Risk factors for noninvasive ventilation failure in cancer patients in the intensive care unit: A retrospective cohort study
    Ferreira, Juliana Carvalho
    Medeiros, Pedro, Jr.
    Rego, Francinni Mambrini
    Caruso, Pedro
    JOURNAL OF CRITICAL CARE, 2015, 30 (05) : 1003 - 1007
  • [43] Prediction of acute kidney injury in intensive care unit patients
    Guo, Rui-Juan
    Xue, Fu-Shan
    Shao, Liu-Jia-Zi
    CRITICAL CARE, 2018, 22
  • [44] Prediction of acute kidney injury in intensive care unit patients
    Rui-Juan Guo
    Fu-Shan Xue
    Liu-Jia-Zi Shao
    Critical Care, 22
  • [45] Risk factors for hospital mortality in intensive care unit survivors: a retrospective cohort study
    Antonio e Silva, Luiza Gabriella
    de Maio Carrilho, Claudia Maria Dantas
    Talizin, Thalita Bento
    Queiroz Cardoso, Lucienne Tibery
    Lavado, Edson Lopes
    Carvalho Grion, Cintia Magalhaes
    ACUTE AND CRITICAL CARE, 2023, 38 (01) : 68 - 75
  • [46] A retrospective cohort study of the risk factors and outcomes of antibiotic resistance in the intensive care unit
    Mustapha, Mohd Tarmimi
    Hassan, Wan Mohd Nazaruddin Wan
    Mokhtar, Ariffin Marzuki
    Shukeri, Wan Fadzlina Wan Muhd
    Mazlan, Mohd Zulfakar
    ANAESTHESIA PAIN & INTENSIVE CARE, 2021, 25 (04) : 428 - 435
  • [47] Evaluation of determinants of acute kidney injury and mortality among patients attending intensive care unit: A retrospective study
    Zhu, Jun
    Chen, Hong-Guang
    Yang, Rong
    Sun, Lan
    Zou, Qi-Yin
    BIOMEDICAL RESEARCH-INDIA, 2017, 28 (05): : 2250 - 2255
  • [48] Acute gastrointestinal injury in the intensive care unit: a retrospective study
    Chen, HuaiSheng
    Zhang, HuaDong
    Li, Wei
    Wu, ShengNan
    Wang, Wei
    THERAPEUTICS AND CLINICAL RISK MANAGEMENT, 2015, 11 : 1523 - 1529
  • [49] Acute kidney injury in a tropical country: a cohort study of 253 patients in an infectious diseases intensive care unit
    Daher, Elizabeth De Fransceco
    da Silva Junior, Geraldo Bezerra
    Freitas Vieira, Ana Patricia
    de Souza, Juliana Bonfim
    Falcao, Felipe dos Santos
    da Costa, Cristiane Rocha
    Camara da Silva Fernandes, Anna Allicy
    Athayde Lima, Rafael Siqueira
    REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 2014, 47 (01) : 86 - 89
  • [50] Risk Factors for Acute Kidney Injury in Patients Receiving Intravenous Colistin
    Katip, Wasan
    Oberdorfer, Peninnah
    Taruangsri, Puntapong
    Nampuan, Teerapong
    PHARMACEUTICAL SCIENCES, 2024, 30 (02) : 244 - 251