Identification of a serum-based microRNA signature that detects recurrent oral squamous cell carcinoma before it is clinically evident

被引:6
|
作者
Towle, Rebecca [1 ]
Dickman, Christopher T. D. [1 ]
MacLellan, Sara A. [1 ]
Chen, Jiahua [2 ]
Prisman, Eitan [3 ]
Guillaud, Martial [1 ]
Garnis, Cathie [1 ,3 ]
机构
[1] British Columbia Canc Res Ctr, Dept Integrat Oncol, Vancouver, BC, Canada
[2] Univ British Columbia, Dept Stat, Vancouver, BC, Canada
[3] Univ British Columbia, Dept Surg, Div Otolaryngol, Vancouver, BC, Canada
关键词
NECK-CANCER; FOLLOW-UP; CEREBROSPINAL-FLUID; YOUDEN INDEX; FDG PET; HEAD; BIOMARKERS; PROLIFERATION; MIR-342-3P; ACCURACY;
D O I
10.1038/s41416-023-02405-9
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BackgroundSurvival rates for oral squamous cell carcinoma (OSCC) have remained poor for decades, a fact largely attributable to late-stage diagnoses and high recurrence rates. We report analysis of serum miRNA expression in samples from patients with high-risk oral lesions (HRL, including OSCC/carcinoma in situ lesions) and healthy non-cancer controls, with the aim of non-invasively detecting primary or recurrent disease before it is clinically evident. Methods Discovery, test, and validation sets were defined from a total of 468 serum samples (305 HRL and 163 control samples). Samples were analysed using multiple qRT-PCR platforms. Results A two-miRNA classifier comprised of miR-125b-5p and miR-342-3p was defined following discovery and test analyses. Analysis in an independent validation cohort reported sensitivity and specificity of similar to 74% for this classifier. Significantly, when this classifier was applied to serial serum samples taken from patients both before treatment and during post-treatment surveillance, it identified recurrence an average of 15 months prior to clinical presentation. Conclusions These results indicate this serum miRNA classifier is effective as a simple, non-invasive monitoring tool for earlier detection of recurrent disease when lesions are typically smaller and amenable to a wider array of treatment options to improve survival.
引用
收藏
页码:1810 / 1817
页数:8
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