LRRK2 kinase activity regulates GCase activity, glycosphingolipids and BMP in preclinical models and human subjects of PD

被引:0
|
作者
Maloney, M. T. [1 ]
Wang, X. [1 ]
Ghosh, R. [1 ]
Andrews, S. [1 ]
Bondar, V. [1 ]
Davis, O. [1 ]
Chen, J. [1 ]
Ho, A. -N. [1 ]
Masoud, S. [1 ]
Nguyen, H. [1 ]
Arguello, A. [1 ]
De Vicente, J. [1 ]
Maciuca, R. [1 ]
Suh, J. [1 ]
Davis, S. [1 ]
Reyzer, M. L. [2 ]
Zhu, S. [3 ]
Deen, M. [3 ]
Vocadlo, D. [3 ]
Huntwork-Rodriguez, S. [1 ]
Henry, A. G. [1 ]
机构
[1] Denali Therapeut, South San Francisco, CA USA
[2] Vanderbilt Univ, Nashville, TN USA
[3] Simon Fraser Univ, Vancouver, BC, Canada
关键词
D O I
暂无
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
M156
引用
收藏
页码:301 / 301
页数:1
相关论文
共 50 条
  • [31] LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients
    Daniel Ysselstein
    Maria Nguyen
    Tiffany J. Young
    Alex Severino
    Michael Schwake
    Kalpana Merchant
    Dimitri Krainc
    Nature Communications, 10
  • [32] Dependence of Leucine-rich Repeat Kinase 2 (LRRK2) Kinase Activity on Dimerization
    Sen, Saurabh
    Webber, Philip J.
    West, Andrew B.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (52) : 36346 - 36356
  • [33] LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson's disease patients
    Ysselstein, Daniel
    Nguyen, Maria
    Young, Tiffany J.
    Severino, Alex
    Schwake, Michael
    Merchant, Kalpana
    Krainc, Dimitri
    NATURE COMMUNICATIONS, 2019, 10 (1)
  • [34] The role of LRRK2 in regulating microglial activity in Parkinson's disease (PD)
    Brooker, S.
    Thomas, A.
    Krainc, D.
    MOVEMENT DISORDERS, 2024, 39 : S417 - S418
  • [35] Inhibitory role of peroxiredoxin 2 in LRRK2 kinase activity induced cellular pathogenesis
    Yan, Kang
    Zhang, Wenfeng
    Han, Xu
    Chang, Fei
    Liu, Yongjian
    JOURNAL OF BIOMEDICAL RESEARCH, 2020, 34 (02): : 103 - 113
  • [36] LRRK2 is involved in the chemotaxis of neutrophils and differentiated HL-60 cells, and the inhibition of LRRK2 kinase activity increases fMLP-induced chemotactic activity
    Yuichi Mazaki
    Haruka Handa
    Yoshizuki Fumoto
    Takahiro Horinouchi
    Yasuhito Onodera
    Cell Communication and Signaling, 21
  • [37] Inhibitory role of peroxiredoxin 2 in LRRK2 kinase activity induced cellular pathogenesis
    Kang Yan
    Wenfeng Zhang
    Xu Han
    Fei Chang
    Yongjian Liu
    TheJournalofBiomedicalResearch, 2020, 34 (02) : 103 - 113
  • [38] LRRK2 is involved in the chemotaxis of neutrophils and differentiated HL-60 cells, and the inhibition of LRRK2 kinase activity increases fMLP-induced chemotactic activity
    Mazaki, Yuichi
    Handa, Haruka
    Fumoto, Yoshizuki
    Horinouchi, Takahiro
    Onodera, Yasuhito
    CELL COMMUNICATION AND SIGNALING, 2023, 21 (01)
  • [39] LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity
    Parisiadou, Loukia
    Yu, Jia
    Sgobio, Carmelo
    Xie, Chengsong
    Liu, Guoxiang
    Sun, Lixin
    Gu, Xing-Long
    Lin, Xian
    Crowley, Nicole A.
    Lovinger, David M.
    Cai, Huaibin
    NATURE NEUROSCIENCE, 2014, 17 (03) : 367 - 376
  • [40] LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity
    Loukia Parisiadou
    Jia Yu
    Carmelo Sgobio
    Chengsong Xie
    Guoxiang Liu
    Lixin Sun
    Xing-Long Gu
    Xian Lin
    Nicole A Crowley
    David M Lovinger
    Huaibin Cai
    Nature Neuroscience, 2014, 17 : 367 - 376