Synthesis and In Vitro Anticancer Evaluation of Flavone-1,2,3-Triazole Hybrids

被引：8

作者：

Nemeth-Rieder, Alexandra ^{[1
]}

Keglevich, Peter ^{[1
]}

Hunyadi, Attila ^{[2
]}

Latif, Ahmed Dhahir ^{[3
,4
]}

Zupko, Istvan ^{[3
]}

Hazai, Laszlo ^{[1
]}

机构：

[1] Budapest Univ Technol & Econ, Fac Chem Technol & Biotechnol, Dept Organ Chem & Technol, Muegyet Rkp 3, H-1111 Budapest, Hungary

[2] Univ Szeged, Inst Pharmacognosy, Eotvos U 6, H-6720 Szeged, Hungary

[3] Univ Szeged, Dept Pharmacodynam & Biopharm, Eotvos Str 6, H-6720 Szeged, Hungary

[4] Wasit Univ, Fac Med, Dept Pharmacol & Toxicol, Wasit 52001, Iraq

来源：

MOLECULES | 2023年 / 28卷 / 02期

关键词：

flavones; chrysin; kaempferol; hybrids; 1,2,3-triazole; anticancer activity; CLICK CHEMISTRY; DERIVATIVES; FEASIBILITY; CHRYSIN;

D O I：

10.3390/molecules28020626

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hybrid compounds of flavones, namely chrysin and kaempferol, and substituted 1,2,3-triazole derivatives, were synthesized by click reaction of the intermediate O-propargyl derivatives. 4-Fluoro- and 4-nitrobenzyl-1,2,3-triazole-containing hybrid molecules were prepared. The mono- and bis-coupled hybrids were investigated on 60 cell lines of 9 common cancer types (NCI60) in vitro as antitumor agents. Some of them proved to have a significant antiproliferative effect.

引用

页数：16

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