Synthesis and In Vitro Anticancer Evaluation of Flavone-1,2,3-Triazole Hybrids

被引：8

作者：

Nemeth-Rieder, Alexandra ^{[1
]}

Keglevich, Peter ^{[1
]}

Hunyadi, Attila ^{[2
]}

Latif, Ahmed Dhahir ^{[3
,4
]}

Zupko, Istvan ^{[3
]}

Hazai, Laszlo ^{[1
]}

机构：

[1] Budapest Univ Technol & Econ, Fac Chem Technol & Biotechnol, Dept Organ Chem & Technol, Muegyet Rkp 3, H-1111 Budapest, Hungary

[2] Univ Szeged, Inst Pharmacognosy, Eotvos U 6, H-6720 Szeged, Hungary

[3] Univ Szeged, Dept Pharmacodynam & Biopharm, Eotvos Str 6, H-6720 Szeged, Hungary

[4] Wasit Univ, Fac Med, Dept Pharmacol & Toxicol, Wasit 52001, Iraq

来源：

MOLECULES | 2023年 / 28卷 / 02期

关键词：

flavones; chrysin; kaempferol; hybrids; 1,2,3-triazole; anticancer activity; CLICK CHEMISTRY; DERIVATIVES; FEASIBILITY; CHRYSIN;

D O I：

10.3390/molecules28020626

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hybrid compounds of flavones, namely chrysin and kaempferol, and substituted 1,2,3-triazole derivatives, were synthesized by click reaction of the intermediate O-propargyl derivatives. 4-Fluoro- and 4-nitrobenzyl-1,2,3-triazole-containing hybrid molecules were prepared. The mono- and bis-coupled hybrids were investigated on 60 cell lines of 9 common cancer types (NCI60) in vitro as antitumor agents. Some of them proved to have a significant antiproliferative effect.

引用

页数：16

共 50 条

[1] Synthesis and Anticancer Evaluation of Tryptanthrin-1,2,3-Triazole Hybrids
Meenakshy, C. B.
Sruthi, Sudheendran Leena
Jayasree, E. G.
Sandhya, Karakkadparambil Sankaran
Deepthi, Ani
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2024, 61 (11) : 1891 - 1898
[2] Design and Synthesis of Isatin-1,2,3-triazole Hybrids as Anticancer Agents
Mohite, Bhavika
Chabhadiya, Bhadreshkumar K.
Kapadiya, Khushal M.
Khedkar, Vijay M.
Jauhari, Smita
CHEMISTRYSELECT, 2024, 9 (47):
[3] 1,2,3-Triazole hybrids as anticancer agents: A review
Alam, Mohammad Mahboob
ARCHIV DER PHARMAZIE, 2022, 355 (01)
[4] Quinoline Consists of 1H-1,2,3-Triazole Hybrids: Design, Synthesis and Anticancer Evaluation
Venkata, Sivarami Reddy Gangireddy
Narkhede, Umesh C.
Jadhav, Vinod D.
Naidu, Challa Gangu
Addada, Ramakrishnam Raju
Pulya, Sravani
Ghosh, Balaram
CHEMISTRYSELECT, 2019, 4 (48): : 14184 - 14190
[5] 1,2,3-Triazole tethered β-lactam-Chalcone bifunctional hybrids: Synthesis and anticancer evaluation
Singh, Pardeep
Raj, Raghu
Kumar, Vipan
Mahajan, Mohinder P.
Bedi, P. M. S.
Kaur, Tandeep
Saxena, A. K.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 47 : 594 - 600
[6] Novel benzoxepine-1,2,3-triazole hybrids: synthesis and pharmacological evaluation as potential antibacterial and anticancer agents
Kuntala, Naveen
Telu, Jhonsee Rani
Banothu, Venkanna
Nallapati, Suresh Babu
Anireddy, Jaya Shree
Pal, Sarbani
MEDCHEMCOMM, 2015, 6 (09) : 1612 - 1619
[7] Oxazolone-1,2,3-Triazole Hybrids: Design, Synthesis and Antimicrobial Evaluation
Lal, Kashmiri
Kumar, Lokesh
Kumar, Ashwani
Kumar, Anil
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2018, 18 (17) : 1506 - 1513
[8] Synthesis and in vitro biological evaluation of (iso)quinoline-1,2,3-triazole derivatives as anticancer agents
Theeramunkong, Sewan
Maicheen, Chirattikan
Krongsil, Rinnara
Chaichanasap, Waritsara
Asasutjarit, Rathapon
Vajragupta, Opa
CHEMICAL PAPERS, 2022, 76 (06) : 3971 - 3985
[9] Synthesis and in vitro biological evaluation of (iso)quinoline-1,2,3-triazole derivatives as anticancer agents
Sewan Theeramunkong
Chirattikan Maicheen
Rinnara Krongsil
Waritsara Chaichanasap
Rathapon Asasutjarit
Opa Vajragupta
Chemical Papers, 2022, 76 : 3971 - 3985
[10] New maleimide 1,2,3-triazole hybrids: design, synthesis, anticancer, and antimicrobial activities
Salameh, Bader A.
Abu-Safieh, Kayed A.
Al-Hushki, Eman H.
Talib, Wamidh H.
Al-ataby, Israa A.
Al-Qawasmeh, Raed A.
MONATSHEFTE FUR CHEMIE, 2020, 151 (10): : 1609 - 1619

← 1 2 3 4 5 →